Effects of Anthocyanins on Psychological Stress-Induced Oxidative
Stress and Neurotransmitter Status
J. Agric. Food Chem., 56 (16), 7545=967550, 2008.
Effects of Anthocyanins on Psychological Stress-Induced Oxidative
Stress and Neurotransmitter Status
M. Mamunur Rahman,=86 Taka**** Ichiyanagi,=87 Tadazumi Komiyama,=87 ****nji
Sato,=86 and Tetsuya Koni*****=86
Faculty of Applied Life Sciences, Faculty of Pharmaceutical Sciences,
Niigata University of Pharmacy and Applied Life Sciences, 265-1
Higa****jima, Niigata 956-8603, Japan
Received for review March 26, 2008. Revised manuscript received May
26, 2008. Accepted June 23, 2008. This study was sup****ted in part by
a Grant in Aid from AOA Japan Co., LTD., and also from the Uchida
Science Promotion Foundation, Niigata, Japan.
Abstract:
There is strong evidence that oxidative stress participates in the
etiology of neurodegenerative diseases such as Parkinson=92s, and
Alzheimer=92s diseases.
Moreover, emotional stress effects in the central nervous system play
a vital role in homeostasis.
The protective effect of anthocyanins on the cerebral oxidative stress
was studied using the whiskers cut model.
In mice, such treatment causes psychological or emotional distress
leading to oxidative stress in tissues.
To investigate the in vivo antioxidant activity of anthocyanins, an
extract of Vaccinium myrtillis L., an anthocyanin mixture, was orally
administered (100 mg/kg of body weight.) to mice for 7 days, and then
psychological stress was *****sed by cutting off their whiskers.
Whisker removal increased both protein carbonyl formation and lipid
peroxidation in the brain, heart, kidney, and liver.
Further, the levels of oxidative markers showed regional differences
in the brain.
Concomitantly, dopamine neurotransmitter levels were altered in both
the midbrain and the brain cortex.
Orally administered anthocyanins were also active in the brain,
suppressing stress-induced cerebral oxidative stress and dopamine
abnormalities in distressed mice.
These effects of anthocyanin treatment suggest their possible
usefulness for the treatment of cerebral disorders related to
oxidative stress.
Keywords: Anthocyanin; antioxidant activity; psychological stress;
dopamine.
10.1021/jf800930s
Web Release Date: July 29, 2008
Copyright =A9 2008 American Chemical Society
--------------------
http://www.chiro.org/nutrition/FULL/Anthocyanins.shtml
=46rom the December 2001 Issue of Nutrition Science News
By Marilyn Sterling, R.D.
These plant pigments are more than coloring agents for fruit juices,
wine, and other beverages. They also contain an array of health-
promoting benefits.
Eaten in large amounts by primitive humans, anthocyanins are
antioxidant flavonoids that protect many body systems.
They have some of the strongest physiological effects of any plant
compounds, and they are also things of beauty: anthocyanins provide
pigment for pansies, petunias, and plums. (Anthocyanins are a separate
class of flavonoids from proanthocyanidins, discussed in NSN 2000;5(6):
231-4.)
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