Iron localization in superficial siderosis of the central nervous
system.
Kellermier H, Wang G, Wiley C
Neuropathology 2008 Aug 7.
Originally conceived as an uncommon disorder, with the advent of MRI,
CNS superficial siderosis has been observed more frequently. We
present histologic, histochemical, immunohistochemical,
immunofluorescent and ultrastructural evaluation of a 56-year-old
woman with superficial siderosis.
Iron was concentrated in macrophages, superficial astrocytes and gray
matter oligodendroglia deep within the cord.
While spatially associated with dystrophic glial and neuronal
spheroids, iron did not colocalize with mitochondria.
Neurotoxic effects were observed despite selective iron localization
only within a variety of non-neuronal cell types.
Neuropathology : official journal of the Japanese Society of
Neuropathology [Neuropathology]
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