"Unrelated to the aneurysm"
I disagree.
With the high rate of aneurysm in those with hyperviscosity and the
high rate of hyperviscosity in those WITH .. multiple sclerosis .. ?
By A. Chris Gajilan
CNN Medical producer
LOS ANGELES, California (CNN) -- Actress-comedian Teri Garr may be
best known for her roles in iconic 1980s films "Mr. Mom" and
"Tootsie," but in the past few years, she's probably done as many
interviews focusing on her health as on her acting career.
Teri Garr speaks in May at Race to Erase MS, an annual multiple
sclerosis fund-raising event.
"Those were two of my favorite movies and they were about role
reversal," says Garr. "How come women are treated differently from men
all the time? Not only handicapped people, but women -- and
handicapped women forget it!"
The words "handicapped" and "disabled" are not new to Garr. In 2006,
Garr suffered a ruptured brain aneurysm that almost killed her.
"I went to sleep to take a nap and my daughter couldn't wake me up.
So, thank god she called 9-1-1 and they rushed me to the hospital,"
recounts Garr whose daughter, Molly, is now 14.
Garr was in a coma for a week and remembers nothing from that time
period. But months of rehabilitation and recovery are still fresh in
her mind, as is the impact it had on her daughter.
"She had to write an essay at school about something very
meaningful ... and she wrote about 'my mother's aneurysm.' And I read
this thing and I cried. I had no idea that it affected her so much."
Dr. Sanjay Gupta re****ts on Teri Garr's recovery =BB
The brain aneurysm wasn't Garr's first major health battle. Unrelated
to the aneurysm, she has spent decades dealing with an elusive disease
that affects 400,000 Americans. She began to feel mysterious symptoms
on the set of 1982's "Tootsie." Her role would later be nominated for
an Academy Award for Best Sup****ting Actress.
Don't Miss
National Multiple Sclerosis Society
"I had no idea. I just felt tingling. Actually, I felt buzzing in my
foot ... and then when I was jogging also, I would get this horrible
pain in my arm like a knife stabbing and I thought well I'm in Central
Park -- well, maybe it is a knife stabbing me, but it wasn't," jokes
Garr.
Various diagnoses and dozens of doctor visits later, Garr says the
health mystery was finally solved 17 years after she first experienced
symptoms. In 1999, she was diagnosed with multiple sclerosis, or MS, a
chronic and often degenerative disease of the central nervous system
including the brain, spinal cord and optic nerves. There is no cure.
It was a difficult diagnosis for Garr who started her career as a
dancer on the "Sonny and Cher Show" and in films starring Elvis
Presley and Annette Funicello. For years, she kept her illness secret
despite rumors swirling around her intermittent limp.
"I was trying to work but I noticed that people, if they had any
inkling of the idea that I was sick or had MS, ... people shunned me.
No work after that," she said.
At times she has been wheelchair-bound or needed a cane to get around.
According to the National Multiple Sclerosis Society, two-thirds of
people who have MS remain able to walk.
"I call it the s*** sucking pig of a disease that treats everyone
differently," says Garr, who wrote about her experience with MS in
"Speedbumps: Flooring It through Hollywood." With typical Garr humor
she says the original title was going to be "Does this Wheelchair Make
Me Look Fat?"
"Some people don't get any symptoms, but I wasn't one of them," she
said.
Since going public with her diagnosis in 2002, she has served as a
chair of the National Multiple Sclerosis Society and a paid
spokesperson for an MS treatment medication.
Health Library
MayoClinic.com: Multiple Sclerosis
"There are several drugs out right now that can't stop multiple
sclerosis, but they can slow it way down," says Garr who has also
suffered side effects. "They also made me puff up like a balloon. So I
looked horrible. I hated that."
Now 63, Garr says she feels fine except for some weakness in her right
arm and right leg. She exercises at least an hour a day and says
comedy keeps her going.
"My next book's title is going to be, 'I Have One Foot in the Grave
and Another on a Banana Peel.' "
This summer, audiences can catch up with Garr in two new independent
films, "Expired" and "Kabluey."
---------------
"By reduction of blood viscosity"
Basic Science Re****ts
Prevention of Rat Cerebral Aneurysm Formation by Inhibition of Nitric
Oxide Synthase
Shunichi Fukuda, MD; Nobuo Ha****moto, MD; Hiroaki Naritomi, MD; Izumi
Nagata, MD; Kazuhiko Nozaki, MD; Soichiro Kondo, MD; Michiharu Kurino,
PhD; Haruhiko Kikuchi, MD
=46rom the Department of Neurosurgery (S.F., N.H., K.N., S.K.) and
Section of Electron Microscopy Laboratory of Anatomic Pathology
(M.K.), Kyoto University Hospital, and the Stroke Care Unit,
Department of Medicine (H.N.) and Department of Neurosurgery (I.N.,
H.K.), National Cardiovascular Center, Osaka, Japan. Dr Fukuda is now
at the Department of Neurosurgery, Maizuru Municipal Hospital, and Dr
Kondo is now at the Department of Neurosurgery, Tokyo Women=92s Medical
University Hospital, Japan.
Correspondence to Shunichi Fukuda, MD, PhD, Department of
Neurosurgery, Maizuru Municipal Hospital, 150=9611 Mizo****ri, Maizuru
City, Kyoto 625-0035, Japan.
Abstract
Background=97Cerebral saccular aneurysm is a major cause of subarachnoid
hemorrhage, one of the cerebrovascular diseases with the highest
mortality. The mechanisms underlying the development of aneurysms,
however, still remain unclear. We have made a series of re****ts on an
animal model of experimentally induced cerebral aneurysms that
resemble human cerebral aneurysms in their location and morphology,
suggesting that the arterial wall degeneration associated with
aneurysm formation develops near the apex of arterial bifurcation as a
result of an increase in wall shear stress. Using the animal model and
human specimens, we examined the role of nitric oxide (NO) in the
degenerative changes and cerebral aneurysm formation.
Methods and Results=97Inducible NO synthase (iNOS) was
immunohistochemically located at the orifice of human and rat
aneurysms. Nitrotyrosine distribution was also seen in the human
aneurysm. Although no iNOS immunostaining was found in normal
arteries, iNOS immunoreactivity was observed in parallel with the
development of early aneurysmal changes in rats. In contrast, during
the early development of aneurysm, endothelial NOS immunostaining in
the endothelium was weakened compared with that in the control
arteries. An NOS inhibitor, aminoguanidine, attenuated both early
aneurysmal changes and the incidence of induced aneurysms. A
defibrinogenic agent, batroxobin, which may diminish shear stress by
reduction of blood viscosity, prevented iNOS induction as well as
early aneurysmal changes.
Conclusions=97The evidence suggests that NO, particularly that derived
from iNOS, is a key requirement for the development of cerebral
aneurysm. The iNOS induction may be caused by an increase in shear
stress near the apex.
Key Words: aneurysm =95 nitric oxide =95 cerebrovascular disorders =95
hemodynamics
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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