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Iron-chelating Green Tea

by "ironjustice@[EMAIL PROTECTED] " <ironjustice@[EMAIL PROTECTED] > Aug 6, 2008 at 07:57 AM

"Iron-chelating and free-radical scavenging green tea extract"

Effect of green tea on iron status and oxidative stress in iron-loaded
rats.
Med Chem. 2008 Jul;4(4):365-70.
Ounjaijean S, Thephinlap C, Khansuwan U, Phisalapong C, ****haroen S,
****ter JB, Srichairata****ool S.
Department of Biochemistry, Faculty of Medicine, Chiang Mai
University, Chiang Mai 50200, Thailand. ssrichai@[EMAIL PROTECTED]
 non-transferrin bound iron (NTBI) is potentially toxic and
contributes to the generation of reactive oxygen species (ROS),
consequently leading to tissue damage and organ dysfunction.
Iron chelators and antioxidants are used for treatment of thalassemia
patients. Green tea (GT) contains catechins derivatives that have many
biological activities. The purpose of this study was to investigate
the iron-chelating and free-radical scavenging capacities of green tea
extract in vivo. Rats were injected ip with ferric citrate together
with orally administered GT extract (GTE) for 4 months. Blood was
collected monthly for measurement of iron overload and oxidative
stress indicators. Plasma iron (PI) and total iron-binding capacity
(TIBC) were quantified using bathophenanthroline method. Plasma NTBI
was assayed with NTA chelation/HPLC. Plasma malonyldialdehyde (MDA)
was determined by using the TBARS method. Erythrocyte oxidative stress
was *****sed using flow cytometry. Levels of PI, TIBC, NTBI and MDA,
and erythrocyte ROS increased in the iron-loaded rats. Intervention
with GT extract markedly decreased the PI and TIBC concentrations. It
also lowered the transferrin saturation and effectively inhibited
formation of NTBI. It also decreased the levels of erythrocyte ROS in
week 4, 12 and 16. Therefore, green tea extract can decrease iron in
plasma as well as eliminate lipid peroxidation in plasma, and destroy
formation of erythrocyte ROS in the rats challenged with iron. The
bifunctional effects could be beneficial in alleviating the iron and
oxidative stress toxicity. In prospective, these GTE activities should
be further examined in thalassemic animals or humans.

PMID: 18673149


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 51 Posts in Topic:
Iron-chelating Green Tea
"ironjustice@[EMAIL   2008-08-06 07:57:10 
Re: Iron-chelating Green Tea
timmythesaint <timward  2008-08-07 00:22:48 
Re: Iron-chelating Green Tea
"Andrew Heenan"  2008-08-07 09:46:29 
Re: Iron-chelating Green Tea
RF <RF@[EMAIL PROTECTE  2008-08-07 20:50:26 
Re: Iron-chelating Green Tea
D_Frumious_B@[EMAIL PROTE  2008-08-10 14:13:00 
Re: Iron-chelating Green Tea
RF <RF@[EMAIL PROTECTE  2008-08-07 10:39:52 
Re: Iron-chelating Green Tea
ironjustice <teamtanne  2008-08-08 21:44:28 
Re: Iron-chelating Green Tea
Chuck <ShorThing7@[EMA  2008-08-09 07:29:39 
Re: Iron-chelating Green Tea
ironjustice <teamtanne  2008-08-09 08:00:56 
Mercuryman
ironjustice <teamtanne  2008-08-09 08:43:27 
Re: Iron-chelating Green Tea
ironjustice <teamtanne  2008-08-09 09:16:19 
Re: Iron-chelating Green Tea
ironjustice <teamtanne  2008-08-09 11:30:16 
Re: Iron-chelating Green Tea
Sylv <Sylv772003@[EMAI  2008-08-09 17:18:10 
Re: Iron-chelating Green Tea
ironjustice <teamtanne  2008-08-09 17:34:49 
Re: Iron-chelating Green Tea
RF <RF@[EMAIL PROTECTE  2008-08-11 09:00:16 
Re: Iron-chelating Green Tea
jay <jaym1212@[EMAIL P  2008-08-09 18:04:14 
Re: Iron-chelating Green Tea
ironjustice <teamtanne  2008-08-09 19:23:32 
Re: Iron-chelating Green Tea
ironjustice <teamtanne  2008-08-09 19:57:20 
Religious Rantings Removed
ironjustice <teamtanne  2008-08-10 10:28:05 
Re: Religious Rantings Removed
anonymous@[EMAIL PROTECTE  2008-08-10 21:07:46 
Re: Religious Rantings Removed
ironjustice <ironjusti  2008-08-10 20:06:15 
Re: Religious Rantings Removed
RF <RF@[EMAIL PROTECTE  2008-08-10 23:06:42 
Re: Religious Rantings Removed
anonymous@[EMAIL PROTECTE  2008-08-11 13:25:42 
Re: Religious Rantings Removed
RF <RF@[EMAIL PROTECTE  2008-08-11 09:06:20 
Re: Religious Rantings Removed
ironjustice <teamtanne  2008-08-11 11:14:00 
Re: Religious Rantings Removed
anonymous@[EMAIL PROTECTE  2008-08-11 18:45:17 
Re: Religious Rantings Removed
"ironjustice@[EMAIL   2008-08-12 12:20:36 
Re: Religious Rantings Removed
anonymous@[EMAIL PROTECTE  2008-08-12 21:28:50 
Re: Religious Rantings Removed
ironjustice <teamtanne  2008-08-12 21:45:25 
Re: Religious Rantings Removed
anonymous@[EMAIL PROTECTE  2008-08-13 12:58:11 
Re: Religious Rantings Removed
ironjustice <teamtanne  2008-08-13 07:13:34 
Re: Religious Rantings Removed
anonymous@[EMAIL PROTECTE  2008-08-13 14:35:17 
Re: Religious Rantings Removed
ironjustice <teamtanne  2008-08-13 08:04:44 
Re: Religious Rantings Removed
anonymous@[EMAIL PROTECTE  2008-08-13 16:01:36 
Re: Religious Rantings Removed
ironjustice <teamtanne  2008-08-12 22:08:51 
Re: Religious Rantings Removed
"trigonometry1972@[E  2008-08-12 23:01:49 
Re: Religious Rantings Removed
ironjustice <teamtanne  2008-08-12 23:04:39 
Re: Religious Rantings Removed
Roger Pearse <roger.pe  2008-08-13 04:55:54 
Re: Religious Rantings Removed
Roger Pearse <roger.pe  2008-08-13 04:58:35 
Re: Religious Rantings Removed
ironjustice <teamtanne  2008-08-13 07:23:48 
Re: Religious Rantings Removed
Jim Carter <cartej@[EM  2008-08-15 20:56:41 
Re: Religious Rantings Removed
"trigonometry1972@[E  2008-08-13 16:59:11 
Re: Religious Rantings Removed
Roger Pearse <roger.pe  2008-08-14 00:59:33 
Re: Religious Rantings Removed
"Jan Drew" <  2008-08-16 21:45:45 
Re: Religious Rantings Removed
"ironjustice@[EMAIL   2008-08-15 18:19:25 
Re: Iron-chelating Green Tea
Chuck <ShorThing7@[EMA  2008-08-10 12:47:43 
Re: Iron-chelating Green Tea
ironjustice <teamtanne  2008-08-11 11:20:53 
Re: Iron-chelating Green Tea
RF <RF@[EMAIL PROTECTE  2008-08-11 14:43:54 
Re: Iron-chelating Green Tea
jay <jaym1212@[EMAIL P  2008-08-11 11:48:52 
Re: Iron-chelating Green Tea
jay <jaym1212@[EMAIL P  2008-08-11 12:17:22 
Re: Iron-chelating Green Tea
"ironjustice@[EMAIL   2008-08-12 08:27:55 

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tan12V112 Sat Nov 22 7:34:58 CST 2008.