"Brain iron ac***ulation"
Genetics of iron regulation and the possible role of iron in
Parkinson's disease.
Neurobiol Dis. 2008 Jul 11.
Rhodes SL, Ritz B.
Medical Genetics Institute, Cedars-Sinai Medical Center, 8700 Beverly
Blvd., MOT 665W, Los Angeles, CA 90048, USA.
Parkinson's disease (PD) is acknowledged as the second most common
neurodegenerative disorder after Alzheimer's Disease. Older age may be
the only unequivocal risk factor for PD although the male to female
ratio is consistently greater than 1 in populations of European
ancestry. Characteristic features of PD include dopaminergic neuron
death in the substantia nigra (SN) pars compacta, ac***ulation of
alpha-synuclein inclusions known as Lewy bodies in the SN, and brain
iron ac***ulation beyond that observed in non-PD brains of a similar
age. In this review article, we will provide an overview of human and
animal studies investigating the contributions of iron in PD, a
summary of human studies of iron-related genes in PD, a review of the
literature on the genetics of iron metabolism, and some hypotheses on
possible roles for iron in the pathogenic processes of PD including
potential interactions between iron and other factors associated with
Parkinson's disease.
PMID: 18675357
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
|
