"General increase in stored iron"
Increased serum ferritin levels in amyotrophic lateral sclerosis (ALS)
patients.
J Neurol. 2008 Jul 18.
Goodall EF, Haque MS, Morrison KE.
Molecular Neurology Group, Division of Neuroscience, Institute of
Biomedical Research, The Medical School, University of Birmingham,
Edgbaston, Birmingham, B15 2TT, UK.
Iron misregulation promotes oxidative stress, a proposed pathological
mechanism in neurodegenerative disease. The aim of this study was to
evaluate serum iron metabolism indicators in 60 amyotrophic lateral
sclerosis (ALS) patients and 44 age matched controls. Serum ferritin
levels were significantly increased in ALS patients compared to
controls (p < 0.001), while no differences in the levels of serum
iron, transferrin, iron saturation or total iron binding capacity were
found. Likewise no differences in C reactive protein (CRP) or
caeruloplasmin were detected, suggesting that the elevated ferritin
levels in ALS did not merely indicate an acute phase response. The
increased ferritin level may reflect a general increase in stored iron
or be a consequence of ongoing muscle degeneration.
PMID: 18677636
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