http://www.chemheritage.org/educationalservices/pharm/tg/asp/asp120.htm
After Columbus, Europeans began to use quinine from Peru for killing
pain. But during the Napoleonic Wars, Britain's Royal Navy blockaded
mainland Europe, cutting it off from its quinine supply.
http://www.scielo.br/scielo.php?pid=S0103-50532006000300010&script=sci_arttext
The capacity of quinine and related drugs to interact with iron seems
to be relevant.
Just thought I'd remind anyone interested .. the role of elevated iron
levels
as the root cause of medical problems.
Med Hypotheses 1998 Mar;50(3):239-51
A chelate theory for the mechanism of action of aspirin-like drugs.
Wang X
Department of Pathology, Cornell University Medical College, New
York,
NY 10021, USA. xw...@[EMAIL PROTECTED]
Two hundred years after the discovery of the pharmaceutical
usefulness
of aspirin, it and aspirin-like drugs, a family with an
ever-increasing number of members, are an indispensable part of
modern
life. However, the question as to how these drugs work in the body
has
remained unsettled. It is postulated here that this group of drugs
may
exert their therapeutic (and adverse) effects by chelating various
physiologically im****tant metallic cations in the body. The
chelate
theory is sup****ted by the vast majority, if not all, of the
observations on these drugs made in the past.
Publication Types:
* Review
* Review, academic
PMID: 9578329, UI: 98237440
_________________________________________________________________
http://news.excite.com/news/r/010928/18/health-iron
Iron Imbalance in Brain May Cause Migraine
Updated: Fri, Sep 28 6:22 PM EDT
By Will Boggs, MD
NEW YORK (Reuters Health) - Abnormalities in the way the brain's
pain
control center handles iron may lead to the development of
migraine
attacks and headaches, according to a study by Kansas researchers.
During migraine, a ****tion of the brain known as the
periaqueductal
gray matter (PAG) may fail to "switch on" to prevent pain, Dr. K.
Michael Welch of the University of Kansas Medical Center in Kansas
City told Reuters Health.
"In migraine, a trigger such as stress activates the PAG but it
does
not switch on because it is dysfunctional," he explained, "or else
switches on an abnormal part."
The result? "Pain instead of no pain," according to Welch.
His team studied levels of iron in the PAG of patients with either
migraine headaches or recurrent, non-migraine headaches and
compared
them to levels in people without headache or migraine.
Changes in iron levels can reflect changes in the way the cells of
the
PAG work, the authors pointed out.
According to the re****t, published in a recent issue of the
journal
Headache, iron levels in the PAG were significantly increased in
patients with migraine and those with headache compared to the
headache-free group.
In fact, the researchers pointed out, the longer patients had
experienced headaches, the higher the iron levels in the PAG were,
though iron levels at the beginning of their illness were still
clearly higher than normal.
Increased iron levels may be both a cause of migraine attacks and
a
result of repeated headaches, the investigators noted.
"Thus, we believe that the increased (iron levels) in our migraine
groups reflect impaired iron (balance), possibly associated with
(nerve) dysfunction or damage," the authors concluded.
"Perhaps the PAG abnormality is essential to the cause of the
headache
in migraine," Welch said. "The gradual deposition of iron
increases
dysfunction, and headaches coalesce from episodic to continuous."
How, then, might one minimize the damage from increased iron
stores?
Welch advised, "Treat episodes quickly and prevent (attacks)
whenever
possible."
SOURCE: Headache 2001;41:629-637.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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