1: J Gastroenterol. 2008;43(5):338-44.
Epub 2008 Jul 1.
Esophageal function worsens with long
duration of diabetes.
Kinekawa F, Kubo F, Matsuda K, Kobaya**** M,
Furuta Y, Fujita Y, Okada H, Muraoka
T, Yamanouchi H, Inoue H, Uchida Y, Masaki T.
Department of Gastroenterology and Neurology,
Kagawa University School of
Medicine, 1750-1, Ikenobe,
Miki-cho, Kita-gun, 761-0793, Japan.
BACKGROUND:
The aim of this study was to *****s the relation****p
between the duration of diabetes and esophageal dysfunction.
METHODS:
We examined 66 patients
with type 2 diabetes. Duration of diabetes was determined
by asking patients and from their medical records.
The patients were divided into three groups according
to the duration of their diabetes:
group A, 1-4 years, n=26;
group B, 5-9 years, n=20; and
group C, 10+ years, n=20.
Ambulatory esophageal 24-h pH and motility
were monitored, and gastroesophageal reflux and
esophageal motility disorders
were estimated in detail.
RESULTS:
When the duration of diabetes was long, the
percentage of time with pH<4 tended to increase.
The amplitude of esophageal peristaltic waves
and the frequency of effective peristalsis were
reduced when the duration of diabetes was long.
A significant correlation was observed between
the duration of diabetes and the frequency of
effective peristalsis. The number of esophageal
peristaltic waves per minute and the percentage
of multipeaked peristaltic waves increased
significantly in group B, and decreased when the
duration of diabetes became longer.
CONCLUSIONS:
Gastroesophageal reflux and
esophageal motility disorders worsened with
long duration of diabetes. These esophageal
dysfunctions should be considered in patients
with long-standing
diabetes.
PMID: 18592151
|
