This is something interesting, I've been taking it on a regular
basis for at least several years. I wonder if it
played a role in my getting better with all the
other stuff I do?
-----------------------------
J Physiol Pharmacol. 2006 Nov;57 Suppl 5:41-50.
Nocturnal secretion of melatonin in patients with upper digestive
tract
disorders.
Klupi=C5=84ska G, Wi=C5=9Bniewska-Jarosi=C5=84ska M, Harasiuk A,
Chojnacki C, Stec-Michalska K,
B=C5,asiak J, Reiter RJ, Chojnacki J.
Department of Gastroenterology and Internal Diseases, Medical
University of Lodz, 1 Haller's Square,
90-647 Lodz, Poland.
gastro@[EMAIL PROTECTED]
the results of many experimental investigations have
shown that melatonin possesses gastroprotective properties.
On the other hand its role in pathogenesis of upper digestive tract
diseases in man still remains unclear. The aim of the study was to
investigate nocturnal secretion of melatonin in patients
with functional and organic diseases of the upper part of digestive
tract. The investigations were carried out in 149 persons, aged 21-51
years, including
healthy subjects (group I, n=3D30),
and patients with
non-erosive gastroduodenal reflux (NERD, group II, n=3D24),
with gastroesophageal reflux disease (GERD, group III, n=3D25),
with functional dyspepsia (FD, according to the Rome III Criteria,
group IV, n=3D36) and with recurrent duodenal ulcer (DUD, group V,
n=3D34). Diagnoses were established on the basis of endoscopic imaging
and histological examination, 24-hour pH-metry and laboratory tests.
Melatonin serum concentration was measured
with ELISA method. Blood samples were taken for examination in red-
lighted room at 10 p.m. and on the following day at 2 and 6 a.m. The
highest concentration of melatonin in all examined groups was
determined at 2 a.m. The average melatonin concentration in healthy
subjects was 34,7 +/- 4,8 pg/ml. In patients with GERD
and DUD melatonin concentration was lower than in
healthy subjects - 27,2 +/- 8,5 pg/ml and 25,5 +/- 6,2 pg/ml
respectively (p < 0,05; p < 0,01).
The highest concentration of melatonin was found in patients with NERD
and FD - 43,2 +/- 10,8 pg/ml and
42,4 +/- 10,1 pg/ml (p < 0,01; p < 0,05).
The findings of this study
sup****t the notion that melatonin exerts beneficial influences on the
upper digestive tract. It is likely that high or relatively correct
secretion of melatonin is sufficient to prevent peptic changes in
esophageal and duodenal
mucosa.
PMID: 17218759
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