On Aug 8, 7:32=A0pm, Kaz <karen.hannah.c...@[EMAIL PROTECTED]
> wrote:
> I found this description of tolerance which describes the body
> mechanism
>
> "Analgesic tolerance occurs primarily through the body's increasing
> production of enzymes involved in the clearance of the opiate. It is
> also believed that a process known as hyperalgesia, or rebound pain
> also assists in the development of tolerance. Hyperalgesia occurs more
> commonly with the use of short acting "prn" regimens, which allow the
> patient to continually cycle in and out of pain. Hyperalgesic
> tolerance has also been associated with the long-term use of morphine,
> and the development of morphine's active metabolite, morphine-6-
> glucuronide (M6G).
>
> M6G has also been linked to incomplete cross-tolerance associated with
> long-term morphine use. In fact, when using morphine at high doses due
> to tolerance, one can often switch to another opioid at 40-60% of what
> would be considered an equivalent dose, due to the effects of the M6G
> metabolite"
>
> from pain.com
>
> I can really identify with that cycling in and out of pain thing.
> Luckily I don't get so many migraines these days, but now and again I
> get a bad one that lasts for days and days. =A0I take something which
> will work for a couple of hours then I'll be back to square one again
> and that just goes on 24 hours a day during which I can't sleep. =A0Its
> always a battle between seeing if I can just wait it out, trying to
> get into to my GP (Don't you love it when you ring up the doctors
> receptionist crying in pain and they say "Oh I can fit you in in 2
> week" =A0!!!) and trying to avoid the ER (I hate hospitals - Is there
> such a thing as ER Phobia - If so I think I have that one).
similar to how a heroin addict needs to keep taking more and more
heroin or other opiates to get "fixed" and to not be sick or a larger
amount of opiates to get a good rush similar to what you are talking
about "being knocked out" its just your body building tolerance over
time. be careful not to get addicted. i know a lot of people who took
opiates for pain and now they are on the methadone clinic for life.
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