In article
<65c48cb4-e9c1-45e9-830e-203e52570b14@[EMAIL PROTECTED]
>, jay
<jaym1212@[EMAIL PROTECTED]
> wrote:
> > I would point to a nexus of factors like cathelicidin, HIF-1a and
> > metallothionein at work in the sebaceous glands. It's been shown that
> > in common acne you've got defective innate antimicrobial production
> > and it's not too many jumps down a few pathways from there until
> > you get to MT.
>
> Per wiki, Cathelicidins found in neutrophils, epithelial cells,
> macrophages, etc are activated by bacteria, viruses, fungi, etc.
> HIF-1a plays an essential role in cellular and systemic responses to
> hypoxia. Metallothionein have the capacity to bind both physiological
> (Zn, Cu, Se,...) and xenobiotic (Cd, Hg, Ag,...) heavy metals.
The wikipedia entry on cathelicidin is at least a year or more out of
date. Don't rely on it. Read the most recent work in Pubmed - *or* the
postings I've made on it outlining all of this which I won't bother to
recapitulate here.
Sorry, I don't do dioxin. I do mercury. I'm not looking to add another
expertise.
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