> Gastrointestinal dysfunction is an im****tant risk factor for
> diseases of the sebaceous glands and is correlated with
> their occurrence and development.
Could be just coincidence, but dioxin effects sebaceous glands, ie
causes chlorance. Dioxin affects areas that are high in fat, ie
breasts, adipose, nervous system, sebaceous glands, glands that
produce ear wax, etc. Dioxin also suppresses the immune system and
causes hyperinflammation in some organs (ie liver, breast) and various
linings including endothelial lining of vascular system. Dioxin could
very easily produce IBD by damaging the thymus, embedding itself in
the vascular and nerves of the gut. Since dioxin continually
recirculates in bile, the bile duct and terminal ileum would likely
suffer damage.
Chloracne, "the hallmark of dioxin intoxication".
Clinical experiences and laboratory studies are described involving a
population of workers who were exposed in a plant making 2,4,5-
trichlorophenoxyacetic acid (2,4,5-T), including a trichlorophenol
runaway reaction. Workers were followed for a period of four years,
and 30 years later a mortality analysis was done on those exposed to
runaway reaction material to determine possible increased risks for
causes of death. Subsequently, a morbidity study on 436 employees
involving three cohorts was carried out to determine the long-term
health effects associated with the production of 2,4,5-T including
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The mortality and
morbidity studies demonstrated that the standardized mortality ratio
for all causes of death was 69, and for cancer at all sites and
cardiovascular disease it was 100 and 68, respectively. The most
significant observations emerging from the morbidity study were that
86% of the exposed persons developed chloracne at some time and that
52.7% still had chloracne on examination 20 to 30 years after the
initial exposure. There appeared to be no evidence, on a long-term
basis, of increased risks for cardiovascular disease, hepatic disease,
renal disease, central and peripheral nerve problems, reproductive
problems, or birth defects among the exposed and those who had
chloracne among the exposed. Studies on the cell kinetics and
pathogenesis of chloracne indicate that TCDD induces the modulation of
undifferentiated sebaceous gland cells to keratinocytes. This action
results in a disappearance of sebaceous glands and substitution of
closed comedones and keratin cysts. Production workers have the
highest frequency and severity of chloracne and systemic effects.
PMID: 2930898
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