Many of these disorders may be linked through cathelicidin.
Cathelicidin is an
anti-inflammatory/anti-allergy/angiogenic/antimicrobial whose synthesis
is triggered by Vitamin D3 and/or butyrate depending on the cell type.
Cathelicidin/barrier dysfunction is already linked to rosacea, acne and
dermatitis (via allergen response) on the skin side and Crohn's/IBD on
the digestive side.
J Dermatol. 2008 Sep;35(9):555-61.
Risk factors for sebaceous gland diseases and their relation****p to
gastrointestinal dysfunction in Han adolescents.
Zhang H, Liao W, Chao W, Chen Q, Zeng H, Wu C, Wu S, Ho HI.
Department of Dermatology, First Affiliated Hospital, Jinan University,
Guangzhou, China.
Sebaceous gland diseases are a group of common dermatological diseases
with multiple causes. To date, a systematic re****t of the risk factors
for sebaceous gland diseases in adolescents has not been published. The
aim of this study was to *****s the prevalence and risk factors for
certain sebaceous gland diseases (seborrhea, seborrheic dermatitis,
acne, androgenetic alopecia and rosacea) and their relation****p to
gastrointestinal dysfunction in adolescents. From August-October,
2002-2005, a questionnaire survey was carried out to obtain
epidemiological data about sebaceous gland diseases. Using random
cluster sampling, 13 215 Han adolescents aged 12-20 years were recruited
from four countries or districts (Macau; Guangzhou, China; Malaysia; and
Indonesia). The statistical software SPSS ver. 13.0 was used to analyze
the data. The prevalence of seborrhea, seborrheic dermatitis, acne,
androgenetic alopecia and rosacea was 28.27%, 10.17%, 51.03%, 1.65% and
0.97%, respectively. Based on multivariate logistic regression analysis,
the risk factors for sebaceous gland diseases included: age; duration of
local residency; halitosis; gastric reflux; abdominal bloating;
constipation; sweet food; spicy food; family history of acne; late night
sleeping on a daily basis; excessive axillary, body and facial hair;
excessive periareolar hair; and anxiety. There was a statistically
significant difference in the prevalence of gastrointestinal symptoms
(halitosis; gastric reflux; abdominal bloating; constipation) between
patients with and without sebaceous gland diseases (chi(2) = 150.743; P
= 0.000). Gastrointestinal dysfunction is an im****tant risk factor for
diseases of the sebaceous glands and is correlated with their occurrence
and development.
Publication Types:
* Research Sup****t, Non-U.S. Gov't
PMID: 18837699
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