> Question: do you suppose the UV is more
> effective because you get a larger dose
> of vitamin D by way synthesis than the
> doses you've chosen to take? Or could
> it be the UV has other interactions
> with your body? I am just brain storming.
Aye, there's the rub.
I'm taking 6000IU orally and getting a 125,000IU bolus depot shot in
muscle every month. That adds up to around 10,000IU daily. When I
first started the oral dose at 10,000IU, I felt great for a few days and
then the effects began to fade. I had a lot of energy, my allergies and
swelling were much improved - basically all the symptoms you'd expect
with low D3 faded away and I felt normal again. I can't get that from
an oral dose any longer but when I'm exposed to at least an hour of
daylight, the vitamin D3-associated symptoms fade again. It's
miraculous.
Given that an oral dose produced a beneficial response the first few
times I tried it, I don't think I'm having problems with trans****t and
absorption - at least not initially. Taking the extra D3 may have set
something into motion, though, that then inhibited uptake or
metabolization. I suspect a pathogen of some sort gumming up the works
but it might be a metabolic break. I'm at a loss here. I don't see how
metabolism should matter since I'm consuming the final product (D3) and
not a precursor.
My physician said something about carnitine and D3 sharing a trans****ter
but I've been unable to find anything really on it. He said the paper
was recent but none of my searches have turned up anything. I mentioned
carnitine trans****ters OCTN2 and Atb0+ to him - which I have speculated
might be downregulated on purpose in a CMV infection - but my doctor
said it wasn't those two. He goes to a lot of conferences so he might
have been exposed to something outside the electronic record available
to me. Has anybody got an idea about this? Loss of a putative vitamin
D3 trans****ter - perhaps through simple allergic inflammation especially
if it's linked to butyrate uptake - but it would not explain the failure
of the depot shots (would it?).
Despite taking D3 in all of these forms for over year, I'm as mildly
deficient in it now (25.7 ng/mL) as I was when I started supplementation.
I've had something similar happen with butyrate. It produced a lot of
initial benefits and then it slid back to a plateau. I think I've
established a clear connection with herpesvirus replication on that one.
My suspicion is that something similar's taking place with vitamin D3
but my evidence of a connection is much thinner. All I've got is this
corrupt IL-10 the virus pumps out. It's suggestive, but hardly
conclusive. As with most aspects of my condition, my thinking appears
to be a few years ahead of the current state of medical research. I
guess I'm just going to focus on killing the viruses and then check my
blood levels again to see if they normalize.
> : Eur J Immunol. 2008 Aug;38(8):2210-8.
>
> 1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells.
>
> Heine G, Niesner U, Chang HD, Steinmeyer A, Zügel U, Zuberbier T,
> Radbruch A,
> Worm M.
>
> Allergy-Center-Charité, CCM, Department of Dermatology and Allergy,
> Charité -
> Universitätsmedizin Berlin, Berlin, Germany.
>
> 1,25-dihydroxyvitamin D(3) (calcitriol) regulates immune responses,
> e.g., inhibits expression of IgE by B cells and enhances expression of
> IL-10 by
> dendritic cells and T cells. We re****t here that activation of human B
> cells by B cell receptor, CD40 and IL-4 signals induces expression of
> the gene for
> 25-hydroxyvitamin-D3-1alpha-hydroxylase (CYP1alpha). Accordingly,
> these B cells generate and secrete significant amounts of calcitriol.
> In activated B cells calcitriol induces expression of the genes Cyp24,
> encoding a vitamin D hydroxylase, and Trpv6, encoding a calcium
> selective channel protein. Calcitriol enhances IL-10 expression of
> activated B cells more than threefold, both by recruiting the vitamin
> D receptor to the promoter of Il-10, and to lesser extent by
> modulation of calcium-dependent signaling. The molecular link in
> activated B
> cells between vitamin D signaling, expression of IgE and IL-10, and
> their ability to produce calcitriol from its precursor, suggest that
> pro-vitamin D
> (25-hydroxyvitamin D(3)) can be used as a modulator of allergic immune
> responses.
>
>
> PMID: 18651709 [PubMed - indexed for MEDLINE]
Thanks for all the helpful research, people.
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