Appl Microbiol. 1968 Nov;16(11):1809-10.
Photodynamic antiviral substance extracted from chlorella cells.
Fukada T, Ho****no M, Endo H, Mutai M, ****rota M.
PMID: 4302282
Nat Immun Cell Growth Regul. 1990;9(2):121-8.
Effect of Chlorella vulgaris extracts on murine cytomegalovirus
infections.
Ibusuki K, Minami****ma Y.
Department of Microbiology, Miyazaki Medical College, Japan.
The host-mediated antiviral effect of Chlorella vulgaris extracts (CVE)
was evaluated in ICR mice against murine cytomegalovirus (MCMV)
infection. Mice treated with 10 mg of CVE on days 3 and 1 before virus
challenge survived lethal infection. The protective effect of CVE was
shown by a decrease in the infectious viruses replicated in the target
organs of CVE-treated ICR mice. CVE also protected mice from
histopathological damage to the target organs due to MCMV infection.
Both the serum interferon (IFN) level and 2'5'-oligoadenylate (2-5A)
synthetase activity were elevated in CVE-treated and MCMV-infected mice,
and were higher than those in the control mice. The natural killer (NK)
activity of spleen cells, which is otherwise deteriorated by lethal MCMV
infection, was remarkably augmented in CVE-treated mice. Neither
virocidal nor virostatic activity of CVE on MCMV was seen in vitro.
Thus, CVE-induced resistance against MCMV seems to be host-mediated. The
protective effect correlated with the augmentation of NK activity of the
spleen cells and serum IFN activity, which inhibited replication of MCMV
in the target organs and subsequently saved the mice from death.
PMID: 1693753
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