Re: Regulatory T-cell numbers directly related to allergic response
by Kofi <kofi@[EMAIL PROTECTED]
>
Jul 20, 2008 at 10:36 PM
> And this has to do with hair loss exactly how?
>
>
Helminths raise Treg levels and impair mast cell degranulation,
specifically via IgG4
<http://www.discover.com/issues/sep-93/features/ofparasitesandpo264/>.
Dosing hair follicles with substance P causes mast cell degranulation in
addition to catagen [PMID 18055548]. There is evidence from human scalp
biopsies that this same mast cell degranulation is behind the fibrosis
seen in baldness [PMID 1390168].
This link would be consistent with the observation that as poor Koreans
and Japanese moved from rural to urban areas in the 20th century they
suddenly experienced Western rates of hair loss. The rural water supply
was likely infested with various helminths.
> Yes Kofi,
>
> we know you can 'cut & paste', which alone makes you smarter than Dr.
> Ernie Primeau.
Let's clear something up. I don't care how smart anybody thinks I am.
You or George Bush having a certain opinion about reality doesn't
actually cause reality to conform to your opinion of it.