Re: HDAC inhibitors like butyrate reduce autoimmunity via IDO/tryptophan

"Kofi" <kofi@[EMAIL PROTECTED]
> wrote in message 
news:kofi-A8D172.01310720072008@[EMAIL PROTECTED]
> While it shouldn't come as any surprise that butyrate and other HDAC
> inhibitors have potential against autoimmunity since they boost FoxP3
> expression and regulatory T-cell numbers, this recent link to IDO is an
> interesting twist.  IDO is indoleamine 2,3-dioxygenase.  It degrades
> tryptophan which is essential to T-cell survival.
>
> Of particular interest is butyrate, the bacterial byproduct of fiber
> digestion in the GI tract.  It¹s an HDAC inhibitor.  Many of these
> autoimmune problems may be the result of a combining a sugary, low-fiber
> American diet with antibiotics - something that¹s probably
> all-too-common in hospitals these days.
>
> There is also evidence from lung cells that IDO is part of the innate
> immune system.
>
> Certain viruses also hijack the IDO system to avoid attack.  There's
> evidence Epstein Barr, responsible for chronic fatigue, HIV/AIDS and
> hepatatis upregulate IDO - perhaps to escape from certain T-cell
> attacks.  Other viruses like the measles can be damaged by IDO.  This
> rang some bells for me since certain autistics have the
> autoimmune/allergic response you'd expect from regulatory T-cell
> depletion
> <http://www.sciencedaily.com/releases/2008/07/080714155301.htm>
and they
> have cryptic measles infections of the gut they can't clear out.
>
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