On Tue, 12 Jun 2007 11:33:46 GMT, Kofi <kofi@[EMAIL PROTECTED]
> wrote:
>Based partly on research highlighted in newsgroups, I'm beginning a
>course of self-administered intramuscular Vitamin D3 shots (aka "Stross"
>or depot therapy). I plan to start out at 100,000 I.U. once every two
>months and after a few months, if necessary, move to more frequent shots
>- perhaps as often as once a month - until I achieve the kind dramatic
>improvement in my health I get from standing in the sun 3+ hours.
>
Why are you standing in the sun so long? Light skinned people need
only 20 minutes to get the maximum daily dose and even people with the
darkest skin don't need more than 2 hours. After these times the
balance is reached where as much vitamin D is detroyed by sunlight as
is produced in the skin by UVB-radiation.
>My last D3 reading about two years ago was 22, which the lab
>incompetently re****ted as only borderline low-normal. I realize now
>that 75 is normal and many of my symptoms pertaining to autoimmunity and
>deficient innate immunity relate directly to inadequate D3 levels. I've
>tried oral and sublingual D3 but I simply can't get enough that way.
>
Vitamin D is fat soluble so it should be taken with food containing
some fat. Also how much vitamin A are you taking? Vitamin A and D
antagonize each other so too much vitamin A could reduce the effect of
vitamin D.
>I know I'm taking certain risks by measuring my progress strictly from
>my symptoms instead of constantly checking my blood levels of vitamin D3
>but that would be horrendously expensive. That said, I have a few
>questions about safety for the group.
>
[...]
>
>3) I'd like to know if there are any obvious and immediate symptoms of
>D3 overdose and what steps can be taken to ameliorate them. For
>instance, what happens if the depot releases too much D3 too quickly.
>
In adults the doses needed for acute poisoning are very large, much
larger than the doses you mentioned. In Australia 600 000 IU of
vitamin D was given to elderly people intramuscularly once a year and
apparently this large dose did not cause acute toxicity:
Diamond TH, Ho KW, Rohl PG, Meerkin M.
Annual intramuscular injection of a megadose of cholecalciferol for
treatment of vitamin D deficiency: efficacy and safety data.
Med J Aust. 2005 Jul 4;183(1):10-2.
PMID: 15992330 [PubMed - indexed for MEDLINE]
<http://www.mja.com.au/public/issues/183_01_040705/dia10054_fm.html>
But in continouous use daily doses exceeding 40 000 IU have been found
to cause toxic effect after several years of use.
--
Matti Narkia
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