"5 weeks of a PUFA blend containing 70% alpha-linolenic acid"
PUFA induce antidepressant-like effects in parallel to structural and
molecular changes in the hippocampus.
Venna VR, Deplanque D, Allet C, Belarbi K, Hamdane M, Bordet R
Psychoneuroendocrinology 2008 Oct 8.
Epidemiological data suggest that omega-3 polyunsaturated fatty acids
(PUFA) consumption may be inversely correlated to the prevalence and
severity of depression but little is known about the underlying
mechanisms.
In this study, we experimentally investigated whether a chronic
supplementation with PUFA may induce antidepressant-like effects in
mice in parallel to brain structural and molecular changes.
Six weeks feeding with a PUFA-enriched diet induced behavioral changes
in the Forced Swim Test (FST), the Tail Suspension Test and the
Novelty-Suppressed Feeding Test.
Moreover, more than 5 weeks supplementation with a PUFA blend
containing 70% alpha-linolenic acid induced antidepressant-like
effects in the FST with an increase in both swimming and climbing
behaviors.
The combination of a shorter duration of PUFA supplementation with a
low dose of imipramine also induced an additive effect in the FST.
Finally, PUFA supplementation was associated with an increase in the
hippocampal volume, an over-expression of both synaptophysin and BDNF,
and a raise in the number of newborn cells.
Besides the possible modulation of brain plasticity, present results
highlight the effectiveness of PUFA given alone or in combination with
antidepressant drug as potential treatment of depressive disorders.
Psychoneuroendocrinology [Psychoneuroendocrinology]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
|
