New Fat-based Anti-wrinkle Lotion Slows Down Aging of Skin, Study
Shows
ScienceDaily (Jun. 6, 2008) =97 Topical applications of a naturally
occurring fat molecule have the potential to slow down skin aging,
whether through natural causes or damage, researchers re****t.
Through both the normal aging process and external factors like UV
damage, smooth, young skin inevitably becomes coarse and wrinkled. The
basis of this wrinkling is that time and damage both lower the
production of new collagen while increasing the levels of enzymes
called MMPs that chew up existing collagen.
Covering up, slowing down, or even stopping the wrinkling process has
become a big business, and as part of this research endeavor, Jin Ho
Chung and colleagues tested seven naturally occurring lipids (greasy
molecules that play many im****tant biological roles) in their ability
to reduce skin aging.
In samples of skin cells, three of the lipids could prevent UV-
radiation from both reducing collagen expression and increasing the
levels of MMPs; they even increased collagen in undamaged skin cells.
Of these three, the molecule phosphatidylserine (PS) seemed the most
promising, so the researchers tested it on human skin.
They applied a 2% PS solution to small areas of the buttock in both
young and old volunteers; the young skin was subsequently given a dose
of UV-radiation to simulate sun damage. In both natural and UV-induced
aging, PS treatment prevented collagen reduction and an increase in
MMPs when compared to no treatment.
While larger and longer trials are needed to confirm any therapeutic
benefits, these initial findings suggest topical PA application might
be a simple and natural way to slow down the biological elements
underlying wrinkling.
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http://www.naturalnews.com/016646.html
"Phosphatidylserine from soy lecithin contains mainly polyunsatured
fatty acids, while phosphatidylserine derived from bovine brain
contains mainly saturated and monounsaturated fatty acids, as well as
some docosahexaenoic acid."
-------------------------------------
Journal of Lipid Research, Vol. 49, 1235-1245, June 2008
Copyright =A9 2008 by American Society for Biochemistry and Molecular
Biology
Phosphatidylserine prevents UV-induced decrease of type I procollagen
and increase of MMP-1 in dermal fibroblasts and human skin in vivo
Soyun Cho*,,,**, Hyeon Ho Kim*,,, Min Jung Lee*,,, Serah Lee*,,, Chang-
Seo Park, Sang-June Nam, Jeong-Jun Han, Jin-Wook Kim and Jin Ho
Chung1,*,,
* Department of Dermatology, Seoul National University College of
Medicine, Seoul, Korea
Laboratory of Cutaneous Aging Research, Clinical Research Institute,
Seoul National University Hospital, Seoul, Korea
Institute of Dermatological Science, Seoul, Korea
** Boramae Hospital, Seoul National University, Seoul, Korea
Department of Chemical and Biochemical Engineering, Dongguk
University, Seoul, Korea
Doosan Biotech Division, Gyeonggido, Korea
This work was sup****ted in part by Grant A040008 from the Korea Health
21 R & D Project, Ministry of Health and Welfare, Republic of Korea.
Published, JLR Papers in Press, March 12, 2008.
1 To whom correspondence should be addressed. e-mail:
jhchung@[EMAIL PROTECTED]
an effort to find topical agents that prevent or retard cutaneous
aging, seven functional lipids were screened for their procollagen-
upregulating and matrix metalloproteinase (MMP)-1-downregulating
activities in human dermal fibroblasts by Western blotting. The
preventive effect on ultraviolet (UV)-induced decrease of procollagen
was demonstrated in phosphatidylserine (PS), lysophosphatidylserine
(LPS), lysophosphatidic acid (LPA), N-acetyl phytosphingosine (NAPS),
and tetraacetyl phytosphingosine (TAPS). Furthermore, PS, LPS, and LPA
upregulated procollagen expression in unirradiated basal conditions.
The inhibitory effect on UV-induced MMP-1 expression was seen in NAPS,
TAPS, LPA, PS, lysophosphatidylglycerol, and LPS. PS was chosen as the
most suitable candidate anti-aging chemical for the subsequent in vivo
studies. We investigated the effects of PS on acute UV response and
chronologic skin aging by topically applying it to young skin before
UV irradiation and to aged human skin, respectively. Real-time PCR and
Western blot revealed that in the young skin, PS treatment prevented
UV-induced reduction in procollagen expression and inhibited UV-
induced MMP-1 expression. PS also blocked UV-induced IL-6 and COX-2
gene expression in cultured fibroblasts dose-dependently. In the aged
skin, PS caused increased procollagen transcription and procollagen
immunostaining in the upper dermis, and a significant decrease in
MMP-1 expression at both mRNA and protein levels. These results
indicate that topical PS has anti-skin-aging properties and point to
the potential use of PS as a therapeutic agent in the prevention and
treatment of cutaneous aging.
Supplementary key words ultraviolet =95 intrinsic aging =95 photoaging =95
matrix metalloproteinase-1
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