This drug they use to treat altitude sickness or the human model of
iron overload.
It seems it works by downregulating the production of erythropoietin
the hormone which causes increased production of red blood cells.
So the result being .. fewer red blood cells.
"Therapeutic implications in secondary polycythemia"
Glorified .. bloodletting.
------------------------
Medicines for Epilepsy: DiamoxDiamox (DI-a-mox) was introduced as an
antiepileptic drug in 1952. It has been used to treat a variety of
seizure types, including generalized tonic clonic, ...
www.epilepsyfoundation.org/answerplace/Medical/treatment/medications/typesme=
dicine/diamox.cfm
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Journal of Wilderness Medicine: Vol. 5, No. 3, pp. 312=96317.
Acetazolamide reduces the erythropoietin response to hypoxia at high
altitude in humans
WALTER H. REINHART, MD; STEFAN GOERRE, MD; PETER B=C4RTSCH, MD
Internal Medicine, Kantonsspital, CH-7000 Chur, Switzerland
Department of S****ts Medicine, University of Heidelberg D-6900
Heidelberg, Germany
Objective: Acetazolamide, a carbonic anhydrase inhibitor, is often
used as a prophylactic drug for acute mountain sickness. It may
interfere with erythropoietin production due to its action on
ventilation and renal function.
Design: A randomized, double-blind, placebo-controlled trial with 2 =D7
250 mg acetazolamide daily beginning one day before ascent from 590 m
to 4559 m.
Setting: High-altitude research facilities at the Capanna Regina
Margherita (Italy) at an altitude of 4559 m.
Participants: Eighteen healthy volunteers, aged 24=9642 years.
Main outcome measure: Plasma erythropoietin was measured by
radioimmunoassay before and after the ascent.
Results: The increase of erythropoietin at high altitude was smaller
in the acetazolamide group (increase by 10.8 =B1 7.8 U/L or 58%) than in
the placebo group (increase by 22.7 =B1 13.8 U/L or 113%, p < .0l).
Conclusion: Acetazolamide reduces the erythropoietin response to
hypoxia in humans, which might also have therapeutic implications in
conditions such as secondary polycythemia.
Key Words: acetazolamide, erythropoietin, high altitude
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Tom
Jesus Was A Vegetarian!
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