Potential involvement of iron in the pathogenesis of peritoneal
endometriosis.
Defr=E8re S, Lousse JC, Gonz=E1lez-Ramos R, Colette S, Donnez J, Van
Langendonckt A
Mol Hum Reprod 2008 May 28.
The aim of this study is to review the current literature associating
endometriosis with iron and to discuss the potential causes and
consequences of iron overload in the pelvic cavity.
Indeed, iron is essential for all living organisms.
However, excess iron can result in toxicity and is associated with
pathological disorders.
In endometriosis patients, iron overload has been demonstrated in the
different components of the peritoneal cavity (peritoneal fluid,
endometriotic lesions, peritoneum and macrophages).
Animal models allow us to gather essential information on the origin,
metabolism and effect of iron overload in endometriosis, which may
originate from erythrocytes carried into the pelvic cavity mainly by
retrograde menstruation.
Peritoneal macrophages play an im****tant role in the degradation of
these erythrocytes and in subsequent peritoneal iron metabolism.
Iron overload could affect a wide range of mechanisms involved in
endometriosis development, such as oxidative stress or lesion
proliferation.
In conclusion, excess iron ac***ulation can result in toxicity and
may
be one of the factors contributing to the development of
endometriosis.
Treatment with an iron chelator could thus be beneficial in
endometriosis patients to prevent iron overload in the pelvic cavity,
thereby dimini****ng its deleterious effect.
Molecular human reproduction [Mol Hum Reprod]
----------------------------
Iron overload in the peritoneal cavity of women with pelvic
endometriosis
A. van Langendonckt ; F. Casanas-Roux ; J. Donnez1
Fertility and Sterility Volume: 78 Number: 4 Page: 712 -- 718
Objective:
To examine the possible involvement of iron in the
physiopathology of endometriosis.
Design:
Prospective study.Setting:
Department of gynecology in a university hospital.Patient(s): Seventy
patients undergoing laparoscopy.Intervention(s): Collection of
peritoneal fluid (n =3D 57), blood
samples, and biopsy samples from endometrium (n =3D 62) and from
endometriotic (n =3D 33) and normal-appearing peritoneum (n =3D 53).
Main Outcome Measure(s):
Measurement of iron and ferritin in serum and peritoneal fluid and
staining of iron deposits with Prussian blue in tissues.
Result(s):
Iron and ferritin concentrations were significantly higher in the
peritoneal fluid of patients with endometriosis compared with
controls
during the secretory phase.
Higher rates of ferritin and hemosiderin deposits were observed in
the
peritoneum adjacent to red (100%), black (57%), and white (62%)
lesions compared with normal-appearing peritoneum (25%). Deposits
were
more frequent during the secretory phase than the proliferative phase
in healthy peritoneum from controls, whereas they were found
throughout the cycle in the vicinity of lesions in patients with
endometriosis.
Similar rates of iron deposition were observed in the stroma of black
and white lesions and in eutopic endometrium
from patients with endometriosis.
Conclusion(s):
Iron overload was observed in the cellular and peritoneal fluid
compartments of the peritoneal cavity of women with endometriosis.
Iron deposits seem to be related to the presence of
lesions, suggesting that iron may be involved in the pathogenesis of
endometriosis.
=A9 2003 Elsevier Science B.V., Amsterdam. All rights reserved.
Keywords: Human; peritoneal endometriosis; peritoneal fluid; iron;
ferritin;
hemosiderin; mesothelium
Affiliations: 1: ; 2: ; 3: Department of Gynecology, Universite
Catholique de
Louvain, , Brussels, Belgium
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