On 28 Feb 2006 13:21:02 -0800, Mr-Natural-Health wrote in
<news:1141161662.064691.230630@[EMAIL PROTECTED]
> on
alt.sup****t.diet.low-carb,alt.sup****t.diet.paleolithic,alt.health.diabetes,misc.health.diabetes,sci.med.nutrition
:
Mind the fup2 to smn (i.e., I am asking for replies to please be
posted there and not on all the groups, I don't think this thread is
really on topic on the other groups).
> Br J Nutr. 2002 Aug;88(2):111-6.
>
> Whole grain food intake elevates serum enterolactone.
Is that good?
>
http://docstore.ingenta.com/cgi-bin/ds_deliver/1/u/d/ISIS/26724857.1/cabi/bjn/2002/00000088/00000002/art00003/18A0204A66CF9F0711411613320726F211DEC9C12E.html?link=http://www.ingentaconnect.com/error/delivery%3Bid=2ubab2j65ejc9.victoria&format=html
>
> Jacobs DR Jr, Pereira MA, Stumpf K, Pins JJ, Adlercreutz H.
>
> Division of Epidemiology, School of Public Health, University of
> Minnesota, Minneapolis, USA. jacobs@[EMAIL PROTECTED]
>
> "Both intake of whole grain and higher levels of serum enterolactone
> have been related to reduced risk for CHD and some cancers.
Yes, that's good. :)
> Because
> lignans are prevalent in the outer layers of grains, these findings may
> be related. We carried out a crossover feeding study in which
> overweight, hyperinsulinaemic, non-diabetic men (n 5) and women (n 6)
> ate, in random order, wholegrain foods or refined-grain foods in a diet
> with 30 % energy from fat.
So, they compared the usual diet, so to speak, based on refined carbs
(and some 30% fat) to an alternative diet based on wholegrain foods
(and 30% fat).
> The dominant whole grain was wheat,
And that's pretty usual too.
> followed
> by oats and rice. All food was supplied by the investigators and each
> diet lasted for 6 weeks, with an intervening washout period of 6-9
> weeks. Serum enterolactone concentrations were higher when eating the
> wholegrain than the refined-grain diet by 6.2 (within person SE 1.7)
> nmol/l (P=0.0008). Most of the increase in serum enterolactone when
> eating the wholegrain diet occurred within 2 weeks, though the serum
> enterolactone difference between wholegrain and refined-grain diets
> continued to increase through 6 weeks. Serum enterolactone
> concentrations can be raised by eating a diet rich in whole grains."
That sounds like good news.
> PMID: 12144714
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12144714&dopt=Abstract
However, *all* sources of lignans, including vegetables and fruits,
not only whole grains, have been associated with serum enterolactone
concentration.
===
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12771325&query_hl=2&itool=pubmed_docsum
1: J Nutr. 2003 Jun;133(6):1830-3.
Intake of lignans is associated with serum enterolactone concentration
in Finnish men and women.
Kilkkinen A, Valsta LM, Virtamo J, Stumpf K, Adlercreutz H, Pietinen
P.
Department of Epidemiology and Health Promotion, National Public
Health Institute, Helsinki, Finland. annamari.kilkkinen@[EMAIL PROTECTED]
mammalian lignans (a form of phytoestrogens), metabolically
derived by the intestinal microflora from dietary precursors, may have
several health benefits. Information concerning their dietary sources
and bioavailability is scarce. We *****sed lignan intake via a 24-h
dietary recall (n = 2852) and determined serum enterolactone (EL)
concentration (n = 1784) in 25- to 64-y-old Finnish men and women
participating in a national survey in 1997. Mean intake of lignans
[sum of matairesinol (MAT) and secoisolariciresinol (SECO)] in men and
women was 173 microg/d (19 microg/MJ) and 151 microg/d (23 microg/MJ),
respectively. SECO made up over two thirds of the total lignan intake.
The major sources of SECO were fruit, berries and cereals, whereas MAT
derived almost exclusively from cereals. Lignan intake was positively
associated with serum EL concentration (r = 0.19, P < 0.0001), i.e.,
the mean EL concentration in the highest quintile of lignan intake was
50% higher than that in the lowest quintile. We conclude that lignans
are common components of the Finnish diet, although the mean daily
intake is low (<0.2 mg). The main dietary sources of lignans, i.e.,
whole grain, vegetables and fruits, are foods commonly associated with
lower risk of cardiovascular diseases and cancer. Serum EL
concentration is a feasible biomarker of lignan intake.
Publication Types:
Clinical Trial
Randomized Controlled Trial
PMID: 12771325 [PubMed - indexed for MEDLINE]
Free Full text:
http://www.nutrition.org/cgi/content/full/133/6/1830
===
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15465768&query_hl=2&itool=pubmed_docsum
J Nutr. 2004 Oct;134(10):2691-7.
Intake of whole grains and vegetables determines the plasma
enterolactone concentration of Danish women.
Johnsen NF, Hausner H, Olsen A, Tetens I, Christensen J, K****sen KE,
Overvad K, Tjonneland A.
Institute of Cancer Epidemiology, The Danish Cancer Society,
Copenhagen, Denmark. nina@[EMAIL PROTECTED]
mammalian lignan enterolactone (ENL), which is produced from
dietary plant-lignan precursors by the intestinal microflora, may
protect against breast cancer and other hormone-dependent cancers.
This cross-sectional study examined which variables related to diet
and lifestyle were associated with high plasma concentrations of ENL
in Danish postmenopausal women. Plasma ENL was measured by
time-resolved fluoroimmunoassay in 857 Danish women aged 50-64 y who
participated in a prospective cohort study. Diet was *****sed using a
semiquantitative FFQ, and background information on lifestyle was
collected using a self-administered questionnaire. Multiple analyses
of covariance were completed in two steps. The median plasma ENL
concentration was 27 nmol/L (range 0-455 nmol/L). In covariance
analyses, positive associations were found between consumption of
cereals, vegetables, and beverages and plasma ENL concentration. When
analyzing subgroups of these food groups, the associations were
confined to whole-grain products, cabbage, leafy vegetables, and
coffee. For fat and the nondietary variables, negative associations
between BMI, smoking, and frequency of bowel movements and plasma ENL
concentration were observed. These data show that foods high in ENL
precursors are associated with high concentrations of ENL.
Furthermore, smoking, frequent bowel movements, and consumption of fat
seems to have a negative affect on the ENL concentration. In
conclusion, whole grains and vegetables are the most im****tant dietary
providers of plant lignans for the concentration of ENL in Danish
postmenopausal women, and if ENL is found to protect against cancer or
heart disease, the intake of whole grains and vegetables should be
increased.
PMID: 15465768 [PubMed - indexed for MEDLINE]
Free Full Text:
http://www.nutrition.org/cgi/content/full/134/10/2691
===
Fup2 [Followup-to: / Risposte a:] sci.med.nutrition
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