On Nov 18, 9:11=A0am, "ironjust...@[EMAIL PROTECTED]
" <ironjust...@[EMAIL PROTECTED]
> wrote:
:Liver cancer patients have high diabetes prevalence .
"Indicates that the prevention of liver cancer by iron depletion is
possible" <<
Any heart problems out there .. ?
"We're very excited"
"We just received funding"
"To see if chloroquine can treat heart disease"
"Use of agents which decrease the iron content"
Common cause of heart disease, diabetes may be treatable with malaria
drug
By Michael Purdy
Nov. 7, 2006 -- Studies of a rare genetic condition that increases
cancer risk have unveiled a potential treatment for metabolic
syndrome,
a common disorder that afflicts as many as one in every four American
adults and puts them at sharply increased risk of type 2 diabetes and
clogged arteries.
http://www.sciencedaily.com/releases/2006/11/061108124721.htm
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Effect of chronic chloroquine administration on iron loading in the
liver and reticuloendothelial system and on oxidative responses by
the
alveolar macrophages
Auteur(s) / Author(s)
LEGSSYER R. (1) ; WARD R. J. (2) ; CRICHTON R. R. (1) ; BOELAERT J.
R.
(3) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Unit=E9 de Biochimie, Universit=E9 Catholique de Louvain,
Louvain-la-Neuve, BELGIQUE
(2) Biologie du Com****tement, Universit=E9 Catholique de Louvain,
Louvain-la-Neuve, BELGIQUE
(3) Unit of Renal and Infectious Diseases, Algemeen Ziekenhuis St
Jan,
Brugge, BELGIQUE
R=E9sum=E9 / Abstract
The ability of chloroquine to alter iron loading in the liver,
spleen,
and alveolar macrophages was investigated in iron-loaded or -depleted
rats. Chloroquine significantly reduced incor****ation of iron into
the
liver, spleen, and alveolar macrophages of animals loaded in vivo
with
iron dextran. The ability of these macrophages to respond to
oxidative
stress was assayed by their capacity to release reactive nitrogen
intermediates after lipopolysaccharide (LPS) stimulation. A
significant
reduction in nitrite release was observed in primary cultures of
macrophages isolated from chloroquine/iron dextran-administered rats
in
comparison to macrophages lavaged from rats iron-loaded alone.
Macrophages isolated from iron-deficient rats showed a significant
increase in nitrite after LPS stimulation, whereas nitrite release in
the macrophages lavaged from the rats which had also received
chloroquine during the iron depletion regime was much lower. These
results indicate that the use of agents which decrease the iron
content
and diminish the oxidative response of the cell to altered iron
status
may be of therapeutic value in patients with iron loading,
particularly
of the reticuloendothelial system.
Revue / Journal Title
Biochemical pharmacology (Biochem. pharmacol.) ISSN 0006-2952
CODEN
BCPCA6
Source / Source
1999, vol. 57, no8, pp. 907-911 (36 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier Science, New York, NY, ETATS-UNIS (1958) (Revue)
------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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