High iron has been linked to diabetes developement.
"NIH Clinical Trial / Iron Depletion in Type 2 Diabetes"
Liver cancer is prevented BY iron depletion in Hepatitis.
"None developed hepatocellular carcinoma (HCC)."
One might think the increased liver cancer rates in diabetes may be
related to increased iron .. ?
Liver cancer patients have high diabetes prevalence
Fri Nov 14, 2008
NEW YORK (Reuters Health) - Patients with hepatocellular carcinoma
(HCC) have a significantly higher prevalence of type 2 diabetes
mellitus (DM) compared to the general population, according to
findings from a case-control study conducted in Italy.
"The association of type (DM2) ... with hepatocellular carcinoma (HCC)
has been long suspected," Dr. Valter Donadon, at ****denone Hospital,
and co-authors note in the October 7 issue of the World Journal of
Gastroenterology. "However, the tem****al relation****p between onset of
diabetes and development of HCC, and the clinical and metabolic
characteristics of patients with DM2 and HCC have not been well
examined."
Their study included 465 consecutive Caucasian HCC patients and 490
age- and ***-matched controls.
Overall, 145 hepatocellular carcinoma patients (31 percent) and 62
control cases (13 percent) had type 2 diabetes (odds ratio 3.1).
Moreover, the authors note, diabetes had been diagnosed at least 6
months prior to the diagnosis of hepatocellular carcinoma in 84
percent of cases, suggesting that diabetes may be a cause rather than
a consequence of liver cancer.
Men with DM and HCC were more likely to be treated with insulin than
male diabetics in the control group (38 percent vs 18 percent, p =3D
0.009), leading the researchers to recommend "close surveillance for
HCC in patients with chronic liver disease and DM2, particularly
(among) males and (those) treated with insulin."
They also advise that metabolic control be attempted with insulin-
sensitizers, such as metformin and glitazones, in preference to
insulin or oral secretogogues.
World J Gastroenterol 2008;14:5695-5700.
-------------------
"None of these patients developed hepatocellular carcinoma (HCC)."
http://cancerres.aacrjournals.org/cgi/content/abstract/61/24/8697
Clinical Investigations
Normalization of Elevated Hepatic 8-Hydroxy-2'-Deoxyguanosine Levels
in
Chronic Hepatitis C Patients by Phlebotomy and Low Iron Diet1
Junji Kato, Masayo**** Kobune, Tokiko ****amura, Ganji Kuroiwa, Kohichi
Takada, Rishu Takimoto, Yasuhiro Sato, Ko**** Fujikawa, Minoru
Takaha****, Tetsuji Takayama, Tatsuru Ikeda and Yo****ro Niitsu2
Fourth Department of Internal Medicine [J. K., T. N., G. K., K. T.,
R.
T., Y. S., K. F., M. T., T. T., Y. N.] and Department of Molecular
Medicine [M. K.], Sap****o Medical University School of Medicine, and
Department of Clinical Pathology, Sap****o Medical University Hospital
[T. I.], Sap****o 060-8543, Japan
Ac***ulation of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in DNA, which may
result from the continuous reactive oxygen species (ROS) generation
associated with chronic inflammation, has been re****ted in various
human preneoplastic lesions and in cancerous tissues.
However, no direct causative relation****p between the 8-OHdG formation
and carcinogenesis has been thus far demonstrated in humans.
Directly proving the causality requires showing that depletion of 8-
OHdG levels in tissue by interfering with ROS generation results in a
reduction in cancer.
Chronic hepatitis C virus (HCV) infection is associated with a
high risk of hepatocellular carcinoma (HCC).
Several studies on patients with chronic HCV have shown that hepatic
iron overload is attributable to liver injury and that iron depletion
improved serum aminotransferase levels.
Excess iron is known to generate ROS within cells, which causes
mutagenic lesions, such as 8-OHdG.
In this study, therefore, we have evaluated whether therapeutic iron
reduction (phlebotomy and low iron diet) with a long-term follow-up (6
years) would decrease the hepatic 8-OHdG levels and the risk of HCC
development in patients with chronic HCV.
Patients (34) enrolled were those who had undergone standard IFN
therapy but had no sustained response.
Quantitative immunohistochemistry using the KS-400 image
analyzing system and electrochemical detection was used for 8-OHdG
detection.
With this treatment, elevated hepatic 8-OHdG levels in
patients with chronic hepatitis C (8.3 =B1 4.6/105 dG) significantly
decreased to almost normal levels (2.2 =B1 0.9/105 dG; P < 0.001) with
concomitant improvement of hepatitis severity, including fibrosis,
whereas HCV titers were unaffected.
None of these patients developed HCC.
Thus, long-term iron reduction therapy in patients with chronic
hepatitis C may potentially lower the risk of progression to HCC.
------------------
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Tom
Jesus Was A Vegetarian!
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Man Is A Herbivore!
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DEAD PEOPLE WALKING
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