Evaluation of anti-inflammatory activity of plant lipids containing
alpha-linolenic acid.
Singh S, Nair V, Jain S, Gupta YK
Indian J Exp Biol 2008 Jun; 46(6):453-6.
Two groups of fatty acids are essential to the body, the omega6 (n6)
series derived from linoleic acid (18:2, n-6) and the omega3 (n3)
series derived from alpha-linolenic acid (18:3, n-3).
Fatty acids provide energy, are an integral part of the cell membranes
and are precursors of prostaglandins, thromboxanes and leukotrienes
collectively known as eicosanoids.
Eicosanoids participate in development and synthesis of immunological
and inflammatory responses.
The fixed oils (1, 2, 3 ml/kg) containing alpha-linolenic acid,
obtained from the seeds of Linseed (Linum usitatissimum), Soyabean
(Glycine max) and Holy basil (Ocimum sanctum) were screened for their
antiinflammatory activity using carrageenan, leukotriene and
arachidonic acid induced paw edema models in rats and the
antiinflammatory effects were compared with the standard drug
indomethacin.
Significant inhibition of paw edema was produced by all the oils in
the highest dose (3 ml/kg) in all the models. While O. sanctum oil
produced the maximum percentage inhibition in leukotriene induced paw
edema, L. usitatissimum oil produced maximum percentage inhibition in
carrageenan and arachidonic acid induced paw edema models.
The results show that oils with higher alpha-linolenic acid content
(L. usitatissimum and O. sanctum) produced a greater inhibition of paw
edema suggesting that modulation of the course of inflammatory
disorders may be achieved by altering the eicosanoid precursor (i.e.
poly unsaturated fatty acids: PUFA) availability through dietary
manipulation.
Indian journal of experimental biology [Indian J Exp Biol]
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Alpha-linolenic Acid From Plants
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