> salicylamide is an antagonist of the aryl hydrocarbon ...
Screening of the inhibitory effect of vegetable constituents on the
aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-
tetrachlorodibenzo-p-dioxin.
The aryl hydrocarbon receptor (AhR) is a ligand-activated nuclear
transcription factor that mediates responses to environmental
contaminants such as dioxins, which have many adverse health effects.
We performed a preliminary screening of the inhibitory effects of
vegetable constituents on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-
induced activation of AhR using the AhR-based bioassay for dioxins,
the Ah-Immunoassay. Ninety vegetable constituents including
flavonoids, tannins, saponins, terpenes, etc., were assayed in vitro.
Among them, flavones, flavonols, anthraquinones, piperine, coumestrol,
brevifolincarboxylic acid, and resveratrol showed marked inhibitory
effects on AhR-based bioassay activation by TCDD, and their effects
were dose dependent. Cur***in, carnosol, and capsaicin also inhibited
the activation of AhR in this assay, although to a lesser degree.
These results suggest that several vegetable constituents might play a
role in protection against dioxin toxicity. PMID: 14646185
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