Re: IBD & Dioxins Link?

> salicylamide is an antagonist of the aryl hydrocarbon ...

Anthocyans fail to suppress transformation of aryl hydrocarbon
receptor induced by dioxin.
Dioxins induce adverse effects through transformation of the cytosolic
aryl hydrocarbon receptor (AhR). Our previous study found that
flavones and flavonols at dietary levels suppress AhR transformation.
In the present study, we investigated whether 20 anthocyans dissolved
in trifluoroacetic acid (TFA)-MeOH suppressed AhR transformation in a
cell-free system and in Hepa-1c1c7 cells. Although four compounds at
50 muM suppressed 0.1 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-
induced AhR transformation and their effects were dose-dependent in
the cell-free system, they were ineffective at 0.5 muM, which is close
to physiological concentration. Moreover, no anthocyan at 50 muM
tested here suppressed 0.1 nM TCDD-induced AhR transformation in
Hepa-1c1c7 cells. We also confirmed that protocatechuic acid and
related compounds, which are possible metabolites of anthocyans, did
not affect the transformation in the cell-free system. It is concluded
that anthocyans are not suitable candidates for protection from dioxin
toxicity. PMID: 15914907