Re: IBD & Dioxins Link?

> salicylamide is an antagonist of the aryl hydrocarbon ...

A non-absorbable dietary fat substitute enhances elimination of
persistent lipophilic contaminants in humans.
For individuals contaminated with persistent lipophilic pollutants,
there is an urgent need for a therapy to enhance contaminant
elimination from the body and hence reduce long term exposure. This
study investigated the possibility of enhancing the excretion of
native chemical via the faeces by augmenting the lipophilic properties
of the faeces with the non-absorbable lipid substitute olestra. The
faecal excretion of polychlorinated dibenzo-p-dioxins and
dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), and
hexachlorobenzene (HCB) was measured in 3 volunteers. The excretion
while eating an olestra-free diet was compared with the excretion
while eating a diet supplemented wit 25 g/d of olestra. The excretion
while on the olestra diet was higher by a factor of 1.5-11, depending
on the compound. This resulted from higher concentrations of the
contaminants in the faeces and higher excretion of faeces dry mass due
to the food additive. Using 2,3,7,8-Cl4DD as an example, it was
estimated that ingestion of 25 g/d of olestra would more than double
the overall rate of elimination of this compound from the body. It is
concluded that regular consumption of olestra may provide a
therapeutic approach for reducing the body burden of persistent
lipophilic contaminants. PMID: 10481251