> Resveratrol can help you to lead a long and healthy life ...
Thx for info. I use Country Life's Resveratrol Plus.
Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and
catechol estrogen-mediated oxidative DNA damage in cultured human
mammary epithelial cells.
Resveratrol (3,5,4'-trihydroxystilbene), a naturally occurring
phytoalexin present in grapes and other foods, has been re****ted to
possess chemopreventive effects as revealed by its striking inhibition
of diverse cellular events associated with tumor initiation, promotion
and progression. In our present study, 2,3,7,8-tetrachlorodibenzo-p-
dioxin (TCDD), when treated with the cultured human mammary epithelial
(MCF-10A) cells, induced the expression of cytochrome P450 1A1
(CYP1A1) and 1B1 (CYP1B1) that are responsible for the oxidation of
17beta-estradiol to produce catechol estrogens. Resveratrol strongly
inhibited the TCDD-induced aryl hydrocarbon receptor (AhR) DNA binding
activity, the expression of CYP1A1 and CYP1B1 and their catalytic
activities in MCF-10A cells. It also reduced the formation of 2-
hydroxyestradiol and 4-hydroxyestradiol from 17beta-estradiol by
recombinant human CYP1A1 and CYP1B1, respectively. Furthermore,
resveratrol significantly attenuated the intracellular reactive oxygen
species (ROS) formation and oxidative DNA damage as well as the
cytotoxicity induced by the catechol estrogens. Our data suggest that
CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a
key role in TCDD-induced oxidative damage, and resveratrol can act as
a potential chemopreventive against dioxin-induced human mammary
carcinogenesis by blocking the metabolic formation of the catechol
estrogens and scavenging the ROS generated during their redox cycling.
PMID: 15142886
|
