Re: IBD & Dioxins Link?

> Persistent activation of the AhR is probably responsible for toxic
> responses in experimental animals and humans.

Factors influencing the induction of DNA single strand breaks in rats
by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

The ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to induce
lipid peroxidation and DNA damage in rat hepatic nuclei was
investigated. In addition, the role of iron in hepatic DNA damage was
examined. Female Sprague-Dawley rats were treated with a single dose
of 25--100 micrograms TCDD/kg orally, and sacrificed 3-14 days after
treatment. Liver nuclei were isolated, and DNA single strand breaks
(DNA-SSB) and lipid peroxidation were determined ... TCDD may produce
an increased bioavailability of iron which leads to enhanced DNA
single strand breaks and lipid peroxidation in hepatic nuclei. PMID:
2554534