On Jul 25, 9:55=A0am, jay <jaym1...@[EMAIL PROTECTED]
> wrote:
> > salicylamide is an antagonist of the aryl hydrocarbon ...
>
> Inhibition of dioxin effects on bone formation in vitro by a newly
> described aryl hydrocarbon receptor antagonist,resveratrol.
>
> Aryl hydrocarbon receptor (AhR) ligands are environmental contaminants
> found in cigarette smoke and other sources of air pollution. The
> prototypical compound is TCDD (2,3,7, 8-tetrachlorodibenzo-p-dioxin),
> also known as dioxin. There is an increasing body of knowledge linking
> cigarette smoking to osteo****osis and periodontal disease, but the
> direct effects of smoke-associated aryl hydrocarbons on bone are not
> well understood. Through the use ofresveratrol(3,5,4'-
> trihydroxystilbene), a plant antifungal compound that we have recently
> demonstrated to be a pure AhR antagonist, we have investigated the
> effects of TCDD on osteogenesis. It was postulated that TCDD would
> inhibit osteogenesis in bone-forming cultures and that this inhibition
> would be antagonized byresveratrol. We employed the chicken
> periosteal osteogenesis (CPO) model, which has been shown to form bone
> in vitro in a pattern morphologically and biochemically similar to
> that seen in vivo, as well as a rat stromal cell bone nodule formation
> model. In the CPO model, alkaline phosphatase (AP) activity was
> reduced by up to 50% (P<0.01 vs control) in the presence of 10(-9) M
> TCDD and these effects were reversed by 10(-6) Mresveratrol(P<0.05
> vs TCDD alone). TCDD-mediated inhibition of osteogenesis was
> restricted primarily to the osteoblastic differentiation phase (days
> 0-2) as later addition did not appear to have any effects. Message
> levels for im****tant bone-associated proteins (in the CPO model) such
> as collagen type I, osteopontin, bone sialoprotein and AP were
> inhibited by TCDD, an effect that was antagonized byresveratrol.
> Similar findings were obtained using the rat stromal bone cell line.
> TCDD (at concentrations as low as 10(-10)M) caused an approximately
> 33% reduction in AP activity, which was abrogated by 3. 5x10(-7)
Mresvera=
trol. TCDD also induced a marked reduction in mineralization
> ( approximately 75%) which was completely antagonized byresveratrol.
> These data suggest that AhR ligands inhibit osteogenesis probably
> through inhibition of osteodifferentiation and that this effect can be
> antagonized byresveratrol. Since high levels of AhR ligands are found
> in cigarette smoke, and further since smoking is an im****tant risk
> factor in both osteo****osis and periodontal disease, it may be
> postulated that AhR ligands are the component of cigarette smoke
> linking smoking to osteo****osis and periodontal disease. If
so,resveratro=
lcould prove to be a promising preventive or therapeutic
> agent for smoking-related bone loss. PMID: 11018766
Resveratrol can help you to lead a long and healthy life so says Dr.
Oz.
Red wine alone does not supply enough resveratrol to achieve the
full range of benefits. You need to take high potency resveratrol
supplements to achieve the results do***ented in scientific studies.
Resveratrol Supplements can also help you control your weight
naturally
by increasing energy, reducing cravings, and limiting your appetite.
According to Wikipedia, Consumer Lab, an independent dietary
supplement and over the counter products evaluation organization,
published a re****t on 13 November 2007 on the popular resveratrol
supplements. The organization re****ted that there exists a wide range
in quality, dose, and price among the 13 resveratrol products
evaluated. The actual amount of resveratrol contained in the
different brands range from 2.2mg for Revatrol, which claimed to have
400mg of "Red Wine Grape Complex", to 500mg for Biotivia.com
Transmax,
which is consistent with the amount claimed on the product's label.
Prices per 100mg of resveratrol ranged from less than $.30 for
products made by Biotivia.com, jarrow, and country life, to a high of
$45.27 for the Revatrol brand.
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