> Following abstracts describe TCDD's affect on intestines of monkeys,
> mice and worms...
Chronic Toxicity of Dietary TCDD to Mink.
Mature female natural dark mink (Mustela vison) were fed 0.0006
(control), 0.016, 0.053, 0.180, or 1.40 ppb 2,3,7,8-tetrachlorodibenzo-
p-dioxin (TCDD) for 131-132 d to ascertain the chronic toxic effects
of TCDD in mink, including reproduction. Consumption of the 1.4 ppb
TCDD diet resulted in lethargy, bloody stools, and 16.7% mortality.
Final mink body weights were inversely pro****tional to the dietary
TCDD concentrations. Due to subnormal mink breeding, definitive
effects of TCDD on mink reproductive performance were not ascertained;
however, there were significant dose-dependent decreases in kit (young
mink) birth weight and survival from birth to 3 w of age in the groups
that had reproduction. There were also significant differences in
adult mink white blood cell counts, plasma total solids, serum iron,
phosphorus, albumin, total protein, total CO2, cholesterol,
osmolality, and anion gap concentrations, and alanine
aminotransaminase activity between the various dietary groups. During
the latter stages alopecia and thickened, deformed, and elongated
toenails were observed in the adult mink fed 1.4 ppb TCDD. At
termination the mink fed 1.4 ppb TCDD had ascites, gastric ulcers,
intestinal hemorrhages, depletion of adipose tissue, and mottled and/
or discolored livers, spleens, and kidneys. Focal lymphocytic
meningitis in region of the olfactory bulb was present in 42% of the
mink fed 1.4 ppb TCDD. These results confirmed the high sensitivity of
mink to TCDD and revealed a toenail abnormality not previously
re****ted for mink fed TCDD. PMID: 11383652
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