> ... direct link between IBD and Dioxins? didn't find one, but ...
Below abstract indicates that TCDD lowers corticosterone levels in
rats.
[TCDD alters pituitary-adrenal function. I: Adrenal responsiveness to
exogenous ACTH]
Plasma ACTH concentrations in TCDD-treated rats (50 ug/kg; single,
oral dose) were 2.1-, 2.1-, 2.9-, 1.7-, 1.5-, 2.0- and 3.0-fold
greater than control values, respectively, at days 1, 3, 5, 7, 10, and
14. At days 1 and 5 plasma corticosterone concentrations were
increased 5.1- and 8.0-fold, respectively; whereas, at days 10 and 14
they were depressed to values of 50% and 39% of controls,
respectively. Adrenal glands were excised from rats treated with TCDD
and corticosterone production was *****sed. Basal corticosterone
concentrations produced by treated adrenals were depressed to 81%,
72%, and 71% of control values at days 5, 7, and 14, respectively.
Corticosterone secretion by ACTH stimulated adrenals was equivalent to
controls. These findings suggest that TCDD exposure decreases the
bioactivity of the ACTH secreted by the anterior pituitary. PMID:
8302236
[CORTICOSTERONE STRESS RESPONSE IN TREE SWALLOWS NESTING NEAR
POLYCHLORINATED BIPHENYL AND DIOXIN CONTAMINATED RIVERS.]
We assayed baseline and stress-induced corticosterone concentrations
from adult female and nestling tree swallows, from New England, USA,
sites with different levels of contamination with PCBs and TCDD ...
Altogether these findings suggest that tree swallows chronically
exposed to high PCB and TCDD levels exhibit altered baseline and
stress-induced corticosterone responses, but the patterns of
alteration may not be predictable. PMID: 18476749
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