On Jul 5, 6:32=A0pm, jay <jaym1...@[EMAIL PROTECTED]
> wrote:
> > direct link between IBD and Dioxins? didn't find one, but ...
>
> Below abstract indicate that TCDD can incease TNF:
Pathophysiological mechanisms of TNF during intoxication with natural
or man-made toxins.
Intoxication with different natural toxins or man-made toxicants has
been associated with the induction of tumor necrosis factor alpha
(TNF). These include endotoxin, superantigens, Pseudomonas aeruginosa
exotoxin A, bacterial DNA, T cell stimulatory agents such as agonistic
anti-CD3 mAbs or concanavalin A, alpha-amanitin, paracetamol, ethanol,
carbon tetrachloride, dioxin, and dimethylnitrosamine. In this paper
we compile and discuss the current knowledge on the pathophysiological
role of TNF during intoxication with all mentioned toxins and
toxicants. A possible role of gut-derived endotoxin in several TNF-
dependent toxic events has been considered. The development of
pharmaceuticals that selectively interfere with the detrimental
pathways induced by TNF during intoxication with bacteria, viruses,
drugs, or other chemicals requires detailed knowledge of the signaling
pathways originating from the two TNF receptors (TNFR1 and TNFR2).
Major characteristics of these signaling pathways are described and
put together. PMID: 10576587
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