> ... correlation between UC and a dietary factor?
Modern life' in the epidemiology of inflammatory bowel disease: a case-
control study with special emphasis on nutritional factors.
OBJECTIVE: The rising incidence of inflammatory bowel disease (IBD)
since the Second World War coincides with profound changes of the
dietary pattern. The aim of the study was to investigate the possible
pathogenic role of some characteristic 'modern life' dietary factors
in IBD. DESIGN: Case-control, studying risk factors in recently
diagnosed cases, 290 with Crohn's disease and 398 with ulcerative
colitis, compared with 616 population controls. Smoking, age, gender
and education were taken into account by using logistic regression
analysis. SETTING: Hospital cases and population controls.
INTERVENTIONS: Questionnaires. MAIN OUTCOME MEASURES: Logistic
regression-derived odds ratios. RESULTS: A positive association with
cola drinks [OR: 2.2 (95% CI 1.5-3.1)], chewing gum [OR: 1.5 (95% CI:
1.1-2.1)] and chocolate consumption [OR: 2.5 (95% CI: 1.8-3.5)] and a
negative association with citrus fruit consumption [OR: 0.5 (95% CI
0.3-0.7)] and the development of Crohn's disease were found.
Consumption of cola drinks [OR: 1.6 (95% CI 1.1-2.3)] and chocolate
consumption [OR: 2.5 (95% CI 1.8-3.5)] were positively associated with
developing ulcerative colitis. There was a negative association
between the intake of citrus fruits [OR: 0.5 (95% CI 0.4-0.8)] and
'having a stuffed pet' for a period longer than 5 years [OR: 0.6 (95%
CI 0.4-0.9)] and developing the disorder. No association with the
frequency of tooth bru****ng and developing IBD was found. CONCLUSION:
All the nutritional items mentioned may be true risk factors or they
just might be the expression of a modern life-style also involving
other risk factors for the development of IBD which at the present are
still unknown. PMID: 9585029
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