> ... correlation between UC and a dietary factor?
Pre-illness dietary factors in inflammatory bowel disease.
BACKGROUND: The effect of environmental factors has been demonstrated
in the pathogenesis of inflammatory bowel disease (IBD). Nutrition may
be one of them. AIM: To investigate the pre-illness diet in patients
with recent IBD in comparison with matched population and clinic
controls. METHODS: Quantified dietary histories were obtained from 87
patients with recent IBD (54 ulcerative colitis (UC) and 33 Crohn's
disease (CD)) and 144 controls. Odds ratios (OR) for IBD were derived
for intake levels of various foods. RESULTS: A high sucrose
consumption was associated with an increased risk for IBD (OR 2.85 (p
= 0.03) against population controls and 5.3 (p = 0.00) against clinic
controls). Lactose consumption showed no effect while fructose intake
was negatively associated with risk for IBD (NS). Similar trends were
noted in UC and CD. A high fat intake was associated with an increased
risk for UC; this was particularly marked for animal fat (OR 4.09, p =
0.02) and cholesterol (OR 4.57, p = 0.02). A high intake of fluids (p
= 0.04), magnesium (p = 0.04), vitamin C, and fruits (NS) was
negatively associated with the risk for IBD, while a positive
association was found for retinol (p = 0.01). Most of the findings
were similar in UC and CD except for potassium and vegetable
consumption which showed a negative association only with risk for CD.
CONCLUSIONS: An association was found between pre-illness diet and
subsequent development of UC and CD. The effect of dietary components
may be primary or modulatory. PMID: 9245929
Note: The highest concentration of Persistent Organic Pollutants, ie
PCBs and Dioxins, are found in animal fat.
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