Is there a direct link between IBD and Dioxins? I didn't find one,
but ...
Dioxins, a persistent organic pollutant, resulting from incineration
of chloronated compounds, pesticide manufacturing and pulp/paper
bleaching. Dioxins are released into the atmosphere, rivers, lakes and
oceans. Bacteria can't degrade dioxins. Dioxins ac***ulate in animal
fat. Dioxins work their way to the top of the food chain. The most
potent dioxin is TCDD. Its half life in the human body is about 10
years. At levels as low as a few parts per trillion, TCDD can alter
gene expression of cells, especially those that are growing or
differentiating! Below are a few abstracts farmed from www.pubmed.com
Dioxin - alopecia, hyperkera, choracne, gastric mucosa in monkies.
Dioxin - fatty liver & progressive necrotic lesion in mice.
Dioxin - a risk factor for periodontal diseases.
Dioxin - AhR, cellular energy stress resp; wasting, athero, fatty
liver, thymic atrophy.
Dioxin - chloracne, abnormal liver, peripheral neuropathy,
hyperlipidemia.
Dioxin - induces ROS, esp peroxidation.
TCDD - intestinal cell apoptosis in larvae.
TCDD - changes in gastric mucosa of monkies.
TCDD - low dose, impares mucosal immunity in gut, induces sensitivty
to oral antigens.
TCDD - apoptosis in growing fish's brain, eye, gill, kidney, tail,
intestine, heart, vascular.
TCDD - lung, skin, gastric, intestinal, urinary, bile duct, gall
bladder; liver.
TCDD - spectrum of responses, thymic involution, teratogenesis, tumor,
wasting, epithelial hyperplasia and metaplasia, xenobiotic metab;
immune suppression.
TCDD & Cancer - mitochondrial connection, via ROS.
Because the epithelial cells of the intestines and colon are
constantly undergoing renewal, it seems they would be a preferred
target of TCDD. Any thoughts?
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