Don't forget that you need to titrate the steroids down very slowly. It is
usual to titrate the Prednisolone down to 0 and then the Entocort. If your
adrenal glands have shut down then the final low dose given every second
day
should help to kick start them.
Alternate day dosing with steroids can also prevent the shut down of the
adrenal glands
http://www.google.de/search?hl=de&q=prednisolone+alternate+days+adrenal+glands&meta=
Unlike Prednisolone, which acts systemically, Entocort acts locally with
only some 10% entering the bloodstream, hence the fewer side-effects.
Vanny
"Mark Mandell" <msmandl@[EMAIL PROTECTED]
> schrieb im Newsbeitrag
news:Aeo1k.7498$Ri.1014@[EMAIL PROTECTED]
>
> "Vanny" <Vannyss2003@[EMAIL PROTECTED]
> wrote in message
> news:g1todu$eje$1@[EMAIL PROTECTED]
>>I have been on Entocort (aka Budesonide) since June 2005 with a break
>>between Nov. 2005 and August 2006. I have read somewhere that 3 mg
>>Entocort is equivalent to approximately 10 mg Prednisolone with respect
to
>>efficacy. Because my liver is rebelling (due to Opium, 6-MP, PPIs,
>>Entocort, etc.) I have reduced the Entocort to 3 mg every alternate day
>>with the hope of coming off it sometime because the longterm
side-effects
>>are the same as Prednisolone - it just takes longer to get there. I did
>>start on 9 mg, but had too many side-effects and was OK on 6 mg for a
year
>>or so.
>>
>> Oral Entocort is effective against mild to moderate Crohns located in
the
>> small intestine and ascending colon and is marketed as such.
>> http://www.entocortec.com/HCP/Indications_First.asp
>>
>> If you have Crohn's in the tranverse and/or desdending colon and/or
>> rectum, then an Entocort enema or foam is necessary. If you have severe
>> or fulminant Crohn's then it is unlikely that Entocort will help you.
>> Doses higher than 9 mg per day have not been found to result in
increased
>> efficacy.
>>
http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?id=2616&type=display
>>
>> It sounds Humira as though it would be your best bet. In my experience,
>> one should respond to Entocort within 4-7 days of taking it so you have
>> given it a good shot and it was wise to move on.
>>
>> Side-effects and drug interactions can be found here www.drugs.com and
>> www.rxlist.com
>>
>> Vanny
>>
>> "Mark Mandell" <msmandl@[EMAIL PROTECTED]
> schrieb im Newsbeitrag
>> news:LiV%j.3361$Q57.2204@[EMAIL PROTECTED]
>>> Curious about whether Entocort(Budesonide) users have found it
effective
>>> against Crohn's flareups.
>>>
>>> I ask because I haven't found it quite as effective as Prednisone so
I'm
>>> considering changing to Humira. However, in "defense" of the
Entocort
>>> I will say I haven't taken it all that long. I started in January and
>>> then after two weeks changed to Prednisone(since there was no
>>> improvement)and for five days now, have been on a combined 10 mg. Pred
>>> and 9 mg. of the Entocort(I returned to the Entocort on my doctor's
>>> recommendation since it doesn't have as many side effects as the
Pred).
>>>
>>> Appreciate any feedback.
>>>
>>> Mark Mandell
>
> I'm consulting my GI specialist next week and by then will know for sure
> about remaining on the Combined Entocort and Prednisone I've been
recently
> on.(9 mg. of the Entocort with 10 mg. of the Pred). Inflammation may be
> under control so that the discomfort I have is from post inflammatory
scar
> tissue which neither Humira nor Remicade can eliminate.
>
> Thanks for input thus far.
>
|
