An allele for autophagy is associated with autoimmune digestive
disorders. Butyrate is an HDAC inhibitor and uptake of butyrate can be
impaired in inflammatory gut injuries or via antibiotic usage as
friendly gut bacteria produce butyrate.
Biochem Biophys Res Commun. 2008 May 16;369(4):1179-83. Epub 2008 Mar 13.
Inhibition of histone deacetylase1 induces autophagy.
Oh M, Choi IK, Kwon HJ.
Chemical Genomics Laboratory, Department of Biotechnology, Yonsei
Biomedical Science and Technology Initiative, College of Life Science &
Biotechnology, Yonsei University, 134 ****nchon-dong, Seodaemun-gu, Seoul
120-749, Republic of Korea.
Autophagy is a process where cytoplasmic materials are degraded by
lysosomal machinery. Histone deacetylase (HDAC) inhibitors induce
autophagy, and HDAC6, one of class II HDAC isotypes, is directly
involved in autophagic degradation in the cell. However, it is unclear
if class I HDAC isotype such as HDCA1 is involved in this process. To
investigate if class I HDAC isotype is involved in autophagy, a specific
class I HDAC inhibitor and an siRNA of HDAC1 were used to treat HeLa
cells. Autophagic markers were then investigated. Both inhibition and
genetic knock-down of HDAC1 in the cells significantly induced
autophagic vacuole formation and lysosome function. Moreover, disruption
of HDAC1 leads to the conversion of LC3-I to LC3-II. Together, these
results demonstrate that HDAC1 could play a role in autophagy and
specific inhibition of HDAC1 can induce autophagy.
Publication Types:
* Research Sup****t, Non-U.S. Gov't
PMID: 18342621
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