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Vanny
"ironjustice" <teamtanner@[EMAIL PROTECTED]
> schrieb im Newsbeitrag
news:1170762482.056350.227570@[EMAIL PROTECTED]
Acid Inhibits Histamine Release and Pro-inflammatory Cytokine
Production in Mast Cells
Authors: Kim, Sang-Hyun; Jun, Chang-Duk; Suk, Kyongho; Choi, Byung-Ju;
Lim, Hyunjeung; Park, Seunja; Lee, Seung Ho; ****n, Hye-Young; Kim, Dae-
Keun; ****n, Tae-Yong
Source: Toxicological Sciences, Volume 91, Number 1, May 2006, pp.
123-131(9)
Publisher: Oxford University Press
Abstract:
The discovery of drugs for the treatment of inflammatory allergic
diseases such as, asthma, allergic rhinitis, and sinusitis is a very
im****tant subject in human health. Gallic acid (3,4,5-
trihydroxybenzoic acid), a polyphenyl natural products from gallnut
and green tea, is known to have anti-oxidant, anti-inflammatory, anti-
microbial, and radical scavenging activities. The aim of the present
study was to elucidate whether gallic acid modulates the inflammatory
allergic reaction and to study its possible mechanisms of action.
Gallic acid attenuated compound 48/80- or immunoglobulin E (IgE)-
induced histamine release from mast cells. The inhibitory effect of
gallic acid on the histamine release was mediated by the modulation of
cAMP and intracellular calcium. Gallic acid decreased the phorbol 12-
myristate 13-acetate plus calcium ionophore A23187-stimulated pro-
inflammatory cytokine gene expression and production such as TNF-? and
IL-6 in human mast cells. The inhibitory effect of gallic acid on the
pro-inflammatory cytokine was nuclear factor-?B and p38 mitogen-
activated protein kinase dependent. In addition, gallic acid inhibited
compound 48/80-induced systemic allergic reaction and IgE-mediated
local allergic reaction. The inhibitory activity of gallic acid on the
allergic reaction and histamine release was found to be similar with
disodium cromoglycate. Our findings provide evidence that gallic acid
inhibits mast cell-derived inflammatory allergic reactions by blocking
histamine release and pro-inflammatory cytokine expression, and
suggest the mechanisms of action. Furthermore, in vivo and in vitro
anti-allergic effect of gallic acid suggests a possible therapeutic
application of this agent in inflammatory allergic diseases.
Keywords: gallic acid; inflammatory allergic reaction; mast cell;
histamine; inflammatory cytokine
Do***ent Type: Research article
DOI: 10.1093/toxsci/kfj063
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Tom
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