Thanks to Pam Dowd for sending the following from the evidentiary files
of breast implant litigation.
CAB100170346
INTEROFFICE CORRESPONDENCE
CABOT COR****ATION
PO BOX 165, TUSCOLA, ILLINOIS 61953
JULY 25, 1983
TO: Don Rivin
FROM: Hector Cochrane
SUBJECT: Toxigenics Re****t on Study 420-1171
Dear Don,
This is a follow up to our telephone discussion of today on the above
re****t which we have received recently. A copy of the re****t without
the very extensive Appendix Section is enclosed for your perusal. Dr.
McCunney, Boston office, has a complete copy of the re****t.
The re****t indicated that after 4 weeks exposure of the rats to
CAB-O-SIL=AE N70-TS hydrophobic fumed silica at a level of 30 mg/m3
there is damage to the lung tissue of the rats. After 6 and 12 week
recovery periods, there does appear to be some healing of the tissue.
Toxigenics personnel indicated no evidence of silicosis in the tissue,
however, the exposure of the animal to the hydrophobic silica will
eventually result in some loss of lung capacity through the resultant
scarring in areas affected by the silica.
I would be interested in your comments on the study and the text of the
warning notice with which we will advise our existing and future
customers of these new test results. I will send you a copy of the
latter tomorrow. I would appreciate a reply on this matter by the end
of the week if possible.
Also, for your information, I have enclosed copies of translations of
two inhalation studies carried out on the competitive hydrophobic fumed
silicas, Degussa R972 and Wacker-Chemie H20, by a Dr. Klosterkotter.
At this time, we are planning quite a lot of development work in the
Pilot Plant in 1984 on treated fumed silica, one of which will be a
match for Degussa R972. Obviously, I want to make sure that we take
whatever steps necessary to properly protect our people during these
experiments. I look forward to your comments with interest.
Many thanks for your help in these matters.
Yours sincerely,
Signed: Hector
=20
HC/mc
=20
Cc: RJMcCunney
DRobinson
PFTroiano
Gpaci
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