"Oxidative damage is an im****tant early event"
Malondialdehyde, carbonyl proteins and albumin-disulphide as useful
oxidative markers in mild cognitive impairment and Alzheimer's
disease.
Greilberger J, Koidl C, Greilberger M, Lamprecht M, Schroecksnadel K,
Leblhuber F, ****hs D, Oettl K
Free Radic Res 2008 Jul; 42(7):633-8.
The question arises as to whether oxidative stress has a primary role
in neurodegeneration or is a secondary end-stage epiphenomenon.
The aim of the present study was to determine oxidative stress
parameters like malondialdehyde (MDA), carbonyl proteins (CP) and
Albumin-disulphide (Alb-SSR) and relate these parameters to the immune
parameter neopterin, folic acid and vitamin B12 as vitamins and
homocysteine in patients with neuro-degenerative diseases (NDD),
namely mild cognitive impairment (MCI) and Alzheimer's disease (AD)
compared to an aged matched control group.
MDA, CP and Alb-SSR were significantly increased in the NDD group
compared to controls, but not vitamin B12, folic acid and neopterin.
Significant correlations were found between CP and Alb-SSR, CP and MDA
and between MDA and Alb-SSR including patients with NDD and the
control group.
These results sup****t the hypothesis that oxidative damage to lipids
and proteins is an im****tant early event in the pathogenesis of
neurodegenerative diseases.
Free radical research [Free Radic Res]
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