Cognition and Iron Loading

Amelioration of recognition memory impairment associated with iron
loading or aging by the type 4-specific phosphodiesterase inhibitor
rolipram in rats.
de Lima MN, Presti-Torres J, Garcia VA, Guimar=E3es MR, Scalco FS,
Roesler R, Schr=F6der N
Neuropharmacology 2008 Jun 21.

Increasing evidence indicates that iron deposition in the brain might
play a role in cognitive dysfunction associated with neurodegenerative
disorders and aging. Previous studies have not examined whether iron-
induced memory deficits can be attenuated by acute treatments with
memory-enhancing agents. Phosphodiesterase type 4 (PDE4) inhibitors
such as rolipram (ROL) ameliorate memory impairments in several rodent
models of amnesia and have been proposed as candidate cognitive-
enhancing drugs. Here we show that a single posttraining systemic
injection of ROL dose-dependently attenuates the impairment of memory
for novel object recognition (NOR) in rats given neonatal iron
loading, a model of iron-induced cognitive impairment. Posttraining
administration of ROL also recovered NOR deficits associated with
aging in rats. These findings provide the first evidence that
stimulation of an intracellular second messenger signaling pathway can
attenuate iron-induced memory impairment, and sup****t the view that
PDE4 inhibitors might ameliorate cognitive dysfunction associated with
aging and neurodegenerative disorders.

Neuropharmacology [Neuropharmacology]


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